2026 Publications

Chang MD, Patterson MT, Williams JW.
Sci Transl Med. 2026 Apr 22;18(846):eaef8756. doi: 10.1126/scitranslmed.aef8756.
PMID: 42018667

Wang H.
Front Immunol. 2026 Apr 23;17:1846400. doi: 10.3389/fimmu.2026.1846400. eCollection 2026.
PMID: 42112368

From Lipoprotein Metabolism to Blood Clotting: Highlights of the 2025 Fredrickson Lipid Research Conference.

Smith AN, Beg MA, Hur WS, Ginsburg D, Kullo IJ, Davies SS, Tabas I, Williams JW, Mineo C, Cai B, Gupta RK, Amengual J, Schwendeman A, Graf GA, Sorci Thomas M, Zheng Z.
J Lipid Res. 2026 Apr 16:101041. doi: 10.1016/j.jlr.2026.101041. Online ahead of print.
PMID: 41999980

Wilcox AE, Andres CJ, Bachman MA, Holmes CL.
Infect Immun. 2026 Apr 15;94(4):e0073925. doi: 10.1128/iai.00739-25. Epub 2026 Feb 23.
PMID: 41728977

Bone marrow and splenic immune composition is unperturbed by short-term exposure to bedding from pet store mice.
Little-Letsinger SE, Karmaus PWF, Fessler MB, Hamilton SE.
Immunohorizons. 2026 Apr 11;10(4):vlag014. doi: 10.1093/immhor/vlag014.
PMID: 41968728

An immunobiliary single-cell atlas resolves crosstalk between type 2 conventional dendritic cells and γδ T cells in cholangitis.
Thomann S, Hemmer H, Agrawal A, Basu S, Schaf J, Vornberger N, Krammer T, Sagar, Imdahl F, Poth T, Tóth M, Zielinski CE, Poch T, Krause J, Rosenwald A, Breitkopf-Heinlein K, Rahbari N, Grün D.
Nat Commun. 2026 Apr 10;17(1):3455. doi: 10.1038/s41467-026-71537-2.
PMID: 41963321

Immunotherapy with Guts: A review of microbial therapeutic adjuncts for immunotherapy in solid tumors.
Pum K, Lou E, Goffredo P, Jahansouz C, Subramanian S, Prakash A.
Oncologist. 2026 Apr 9:oyag131. doi: 10.1093/oncolo/oyag131. Online ahead of print.
PMID: 41967083

Fecal Microbiota Transplantation Rapidly Reduces Systemic Inflammation and Resolves C. difficile Pseudomembranous Colitis.
Khoruts A, Kuchma N, Vaughn BP.
Clin Gastroenterol Hepatol. 2026 Apr 6:S1542-3565(26)00233-8. doi: 10.1016/j.cgh.2026.03.023. Online ahead of print.
PMID: 41950979

Guidelines for T cell nomenclature.
Masopust D, Awasthi A, Bosselut R, Brooks DG, Buggert M, Chamoto K, Cui W, Dong C, Farber DL, Gebhardt T, Gerlach C, Goldrath A, Greenberg PD, Hale JS, Hayday A, Homann D, Iannacone M, Jameson SC, Jenkins MK, Joshi NS, Kaech SM, Kallies A, Kamphorst AO, Kaplan MH, Klenerman P, Künzli M, Lanzavecchia A, Lauer GM, Lugli E, Luster AD, Mackay LK, McElrath MJ, Mueller SN, Ndhlovu Z, Ndung'u T, Ohashi PS, Oxenius A, Pantaleo G, Pepper M, Picker LJ, Quarnstrom CF, Reyes-Terán G, Roederer M, Rosato PC, de Oca GS, Sallusto F, Schumacher TN, Schwartz DM, Shin EC, Soerens AG, Thommen DS, Vezys V, Viola JPB, Walker BD, Watts TH, Weaver CT, Wherry EJ, Xue HH, Youngblood B, Ahmed R.
Nat Rev Immunol. 2026 Apr;26(4):298-313. doi: 10.1038/s41577-025-01238-2. Epub 2025 Nov 18.
PMID: 41254224

KLF2 overrides the resident memory CD8 T cell differentiation program, in opposition to KLF3.
DePauw TA, Gai K, Shen J, Maurice NJ, Rhee KH, Valente WJ, O'Connor CH, Cui W, Peng C, Jameson SC.
Proc Natl Acad Sci U S A. 2026 Mar 31;123(13):e2533700123. doi: 10.1073/pnas.2533700123. Epub 2026 Mar 23.
PMID: 41871244

Perinatal microbial exposure and the shaping of the early immune system: lessons from experimental models.
Smith P, Whillock A, Schuldt NJ.
Curr Opin Physiol. 2026 Mar;47:100911. doi: 10.1016/j.cophys.2026.100911. Epub 2026 Feb 16.
PMID: 41858419

Zhang Q, Conrad TS, Moncada-Velez M, Jiang K, Cupic A, Eaton J, Hutchinson K, Gervais A, Chen R, Puel A, Bastard P, Cobat A, Sokol T, Langlois RA, Miorin L, García-Sastre A, Vanchiere JA, Casanova JL.
J Exp Med. 2026 Mar 2;223(3):e20251962. doi: 10.1084/jem.20251962.
PMID: 41348320

IL-4-STAT6 signaling delays protective CD8⁺ T cell bystander activation by antagonizing IL-18 sensing.
Maurice NJ, Dalzell TS, Tankersley TN, Rhee KH, Block KE, Jarjour NN, DePauw TA, Wall SM, Hamilton SE, Jameson SC.
Nat Immunol. 2026 Mar;27(3):476-489. doi: 10.1038/s41590-026-02430-9. Epub 2026 Feb 10.
PMID: 41667619

Krüppel-like factors 2 and 3 regulate T cell exhaustion by directing T cell residency and migration.

Shen J, Brown RJ, Zhang Y, Gai K, Brown AK, Bauer AM, Zhu A, Lin S, Niu H, Kharel A, Xu Z, Cohen GS, Depauw TA, Fagerberg E, Kansas GS, Joshi NS, Jameson SC, Cui W.
Immunity. 2026 Mar 27:S1074-7613(26)00091-9. doi: 10.1016/j.immuni.2026.02.021. Online ahead of print.
PMID: 41903548

Proximity-ligation metagenomics reveals disease-specific mobilome dynamics in disrupted gut ecosystems.
Sommer AJ, Auch B, Khoruts A, Bajaj JS.
Res Sq [Preprint]. 2026 Mar 25:rs.3.rs-9142184. doi: 10.21203/rs.3.rs-9142184/v1.
PMID: 41928791

Basal phosphorylation of SHIP1 by Lyn suppresses proinflammatory signaling in the absence of a phagocytic synapse.
Senevirathne SE, Kanagy WK, Hemmila CR, Greene JT, Rajczewski AT, Cattley RT, Swanson WL, Toledo Ramos S, Nunez MG, Jin S, Hawse WF, Freedman TS.
J Immunol. 2026 Mar 17;215(3):vkaf372. doi: 10.1093/jimmun/vkaf372.
PMID: 41916428

Strengths and limitations of in vitro and animal models to advance understanding of human diet‒microbiome interactions.
Weingarden AR.
Gut Microbes Rep. 2026 Mar 3;3(1):2636336. doi: 10.1080/29933935.2026.2636336. eCollection 2026.
PMID: 41918983

Perinatal microbial exposure and the shaping of the early immune system: lessons from experimental models
Smith P, Whillock A, Schuldt NJ.
Curr Opin Physiol. 2026 Mar;47:100911. doi: 10.1016/j.cophys.2026.100911. Epub 2026 Feb 16.
PMID: 41858419

Non-cognate CD8 Binding to MHC I Promotes Positive Selection of an MHC-E Restricted CD8 T Cell Population.
Yang X, Colden MA, Coombs R, Arana K, Tran D, Valerio MM, Robey EA, Coscoy L.
Eur J Immunol. 2026 Mar;56(3):e70161. doi: 10.1002/eji.70161.
PMID: 41817308

Quantifying Nuance Within Sepsis-Associated Immune Suppression Toward Diagnostic Certainty.
Caldwell CC, Maile R, Mazer MB, McGonagill PW, Bergmann CB, Gould RW, Rao M, Hernández-Ríos M, Ungaro RF, Loftus TJ, Efron PA, Remy KE, Brakenridge SC, Badovinac VP, Griffith TS, Hotchkiss RS, Moldawer LL.
Shock. 2026 Mar 1;65(3):555-559. doi: 10.1097/SHK.0000000000002745.
PMID: 41166166

CXCL10 Regulates Pressure Overload-Induced Heart Failure.
Souza-Neto F, Le P, Abdrabbo M, Alamgir A, Wang H, Ferreira de Araujo N, Mikkila JL, Sanches B, Parthiban P, Moon R, Herman A, Adams AB, Prins KW, Guatimosim S, Schuldt N, Revelo XS, van Berlo JH.
JACC Basic Transl Sci. 2026 Mar;11(3):101462. doi: 10.1016/j.jacbts.2025.101462.
PMID: 42018138

The ageing immune system as a driver of systemic ageing.
Jang IH, Niedernhofer LJ, Robbins PD, Camell CD.
Nat Rev Immunol. 2026 Feb 13. doi: 10.1038/s41577-026-01269-3.
PMID: 41688787

Distinct spatial organization governs oral mucosal immunity.
Theofilou VI, Fraser D, Kanasi E, Brenchley L, Greenwell-Wild T, Adade EE, Valm AM, Douagi I, Belkaid Y, Tran DT, Williams DW, Moutsopoulos NM.
Nat Immunol. 2026 Feb 9. doi: 10.1038/s41590-025-02398-y. Online ahead of print.
PMID: 41663813

Diverse Microbial Exposure Enhances CD8⁺ T Cell Effector Memory Output and Function.
Thefaine CE, Lucas ED, Block KE, Pierson M, Dehm EM, Huggins MA, Casey OW, Zemmour D, Jameson SC, Hamilton SE; immgenT Project.
bioRxiv [Preprint]. 2026 Feb 4:2026.02.02.703037. doi: 10.64898/2026.02.02.703037.
PMID: 41676686

Koenig ZT, Eswar S, Tsuda S, Schuldt N, Chougnet CA, Forde B, Andorf S, Tilburgs T.
Am J Reprod Immunol. 2026 Feb;95(2):e70213. doi: 10.1111/aji.70213.
PMID: 41618722

Dual-functioning Targeted ADAM17 Blocker CD16 (TAB16) mediates selective ADAM17 inhibition in NK cells and engages overexpressed ADAM17 in tumor cells to induce cytotoxicity.
Dixon KJ, Hullsiek R, Wang S, Friess RR, Matson AW, Soignier Y, Lenvik AJ, Wu J, Hart GT, Felices M, Walcheck B.
Front Immunol. 2026 Jan 30;17:1714022. doi: 10.3389/fimmu.2026.1714022. eCollection 2026.
PMID: 41694365

When Smell Drives Swell: Olfr2 Fuels Inflammation in AAA.
Stuttgen GM, Chang M, Williams JW.
Circ Res. 2026 Jan 30;138(3):e327969. doi: 10.1161/CIRCRESAHA.125.327969. Epub 2026 Jan 29.
PMID: 41610191

Ongoing lymphoid HIV production drives pyroptosis and GLP-1 counter-regulation in ART-suppressed infection.
Crawford PA, Rhein J, Chipman JG, Beilman GJ, Cromarty R, Escandón K, Anderson J, Wieking G, Johnston A, Ahmed A, Reichel J, Khoruts A, Basting CM, Kuchma N, Baker JV, Klatt NR, Haase AT, Schacker TW.
bioRxiv [Preprint]. 2026 Jan 10:2026.01.09.698696. doi: 10.64898/2026.01.09.698696.
PMID: 41542439

Toll-Like Receptor 7/8 Antagonist Promotes Interleukin-10-Mediated Anti-inflammatory Therapy.
Funk GA, Xie J, Kucaba TA, Griffith TS, Ferguson DM, Kim H.
ACS Pharmacol Transl Sci. 2025 Dec 11;9(1):114-125. doi: 10.1021/acsptsci.5c00604. eCollection 2026 Jan 9.
PMID: 41536275

A host-adapted commensal fungus from pet store mice drives type 2 immunity and cross-kingdom protection.
Han G, Yunker R, Hasan MH, Bruce A, Baldaro K, Pacia J, Jarjour NN, Beura LK, Vaishnava S.
bioRxiv [Preprint]. 2026 Jan 6:2025.04.30.651489. doi: 10.1101/2025.04.30.651489.
PMID: 41542591

Intrinsic OASL expression governs heterogeneity in interferon induction during influenza A virus infection.
Rivera-Cardona J, Mahajan T, Thayer EA, Kakuturu NR, Teo QW, Lederer J, Rowland EF, Heimburger K, Sun J, McDonald CA, Mickelson CK, Langlois RA, Wu NC, Milenkovic O, Maslov S, Brooke CB.
Proc Natl Acad Sci U S A. 2026 Jan 6;123(1):e2509560123. doi: 10.1073/pnas.2509560123.
PMID: 41468430

Altered natural killer cell function in children with severe malaria
Turyasingura G, Mellencamp KA, Namazzi R, Opoka RO, John CC, Hart GT.
Immunohorizons. 2026 Jan 6;10(1):vlaf070. doi: 10.1093/immhor/vlaf070.
PMID: 41491654

Thymic myeloid cells are heterogenous and include a novel population of transitional dendritic cells.
Vobořil M, Sulczewski FB, Martinez RJ, Ashby KM, Valerio MM, Idoyaga J, Hogquist KA.
J Exp Med. 2026 Jan 5;223(1):e20250733. doi: 10.1084/jem.20250733. Epub 2025 Oct 22.
PMID: 41123595

A Novel Imidazoquinoline With TLR 7/8, STING, and Inflammasome Activity Demonstrates Antitumor Efficacy in Mouse Melanoma and Neu-Driven Mammary Adenocarcinoma.

Bhatnagar S, Revuri V, Merali C, Wang B, Schultz JR, Larson P, Yu D, Prabha S, Griffith TS, Ferguson D, Merali S, Panyam J.
J Immunother. 2026 Jan 1;49(1):1-14. doi: 10.1097/CJI.0000000000000571.
PMID: 40765175