The program project grant "Mechanisms of Peripheral Induction of T-cell Tolerance" is funded for another 5 years.  This grant has been sponsored by NIH for the last 21 years and continues to support great research in CFI.

Since 1993, the National Institute of Allergy and Infectious Diseases (NIAID) has awarded Investigators within the Center for Immunology the ability to examine CD4 and CD8 T cell tolerance mechanisms at the cellular and molecular levels. The program project is titled "Mechanisms of Peripheral Induction of T-cell Tolerance" and the program which is led by Dr. Kris Hogquist includes five projects that will focus on distinct but complementary aspects of tolerance: natural MHCII-bound self epitope discovery, polyclonal anergic cells, type I interferons, non-deletional CD8+ T cell tolerance, and hybrid self-peptides. The relevance of this project focuses on the mechanisms of immune tolerance, with hopes that the results of these studies could lead to new methods for diagnosing diabetes and monitoring immunotherapy. The Center for Immunology would like to congratulate the Jenkins, Jameson, Hogquist, Fife and Mueller labs on their continued success as they start another 5 years of research on developing an increased understanding of T cell tolerance for the prevention or treatment of autoimmune diseases.