2017 Publications

Radiotherapy enhances natural killer cell cytotoxicity and localization in pre-clinical canine sarcomas and first-in-dog clinical trial.
Canter RJ, Grossenbacher SK, Foltz JA, Sturgill IR, Park JS, Luna JI, Kent MS, Culp WTN, Chen M, Modiano JF, Monjazeb AM, Lee DA, Murphy WJ.
J Immunother Cancer. 2017 Dec 19;5(1):98. doi: 10.1186/s40425-017-0305-7.
PMID: 29254507

Cutting Edge: Allograft Rejection Is Associated with Weak T Cell Responses to Many Different Graft Leukocyte-Derived Peptides.
Burrack AL, Malhotra D, Dileepan T, Osum KC, Swanson LA, Fife BT, Jenkins MK.
J Immunol. 2017 Dec 18. pii: ji1701434. doi: 10.4049/jimmunol.1701434. [Epub ahead of print]
PMID: 29255075

Is a Human CD8 T-Cell Vaccine Possible, and if So, What Would It Take? CD8 T-Cell Vaccines: To B or Not to B?
Beura LK, Jameson SC, Masopust D.
Cold Spring Harb Perspect Biol. 2017 Dec 18. pii: a028910. doi: 10.1101/cshperspect.a028910. [Epub ahead of print]
PMID: 29254982

The current status of immunobased therapies for metastatic renal-cell carcinoma.
Sathianathen NJ, Krishna S, Anderson JK, Weight CJ, Gupta S, Konety BR, Griffith TS.
Immunotargets Ther. 2017 Dec 5;6:83-93. doi: 10.2147/ITT.S134850. eCollection 2017. Review.
PMID: 29255699

T Cell-Mediated Beta Cell Destruction: Autoimmunity and Alloimmunity in the Context of Type 1 Diabetes.
Burrack AL, Martinov T, Fife BT.
Front Endocrinol (Lausanne). 2017 Dec 5;8:343. doi: 10.3389/fendo.2017.00343. eCollection 2017. Review.
PMID: 29259578

Increased Effector Memory Insulin-Specific CD4+T-cells Correlate with Insulin Autoantibodies in Recent-Onset Type 1 Diabetic Patients.
Spanier JA, Sahli NL, Wilson JC, Martinov T, Dileepan T, Burrack AL, Finger EB, Blazar BR, Michels AW, Moran A, Jenkins MK, Fife BT.
Diabetes. 2017 Dec;66(12):3051-3060. doi: 10.2337/db17-0666. Epub 2017 Aug 25
PMID: 28842400

Contemporary Applications of Fecal Microbiota Transplantation to Treat Intestinal Diseases in Humans.
Staley C, Khoruts A, Sadowsky MJ.
Arch Med Res. 2017 Nov 25. pii: S0188-4409(17)30235-7. doi: 10.1016/j.arcmed.2017.11.006. [Epub ahead of print] Review.
PMID:29183720

Functional Genomics of Host-Microbiome Interactions in Humans.
Luca F, Kupfer SS, Knights D, Khoruts A, Blekhman R.
Trends Genet. 2017 Oct 26. pii: S0168-9525(17)30182-8. doi: 10.1016/j.tig.2017.10.001. [Epub ahead of print] Review.
PMID: 29107345

Induction of vaginal-resident HIV-specific CD8 T cells with mucosal prime-boost immunization.
Tan HX, Wheatley AK, Esterbauer R, Jegaskanda S, Glass JJ, Masopust D, De Rose R, Kent SJ.
Mucosal Immunol. 2017 Oct 25. doi: 10.1038/mi.2017.89. [Epub ahead of print]
PMID: 29067995

Wait, Wait … OK Now Go In: iNKT Cells Resolve Liver Inflammation.
Wang H, Hogquist KA.
Immunity. 2017 Oct 17;47(4):609-610. doi: 10.1016/j.immuni.2017.10.002.
PMID: 29045892

Design and Synthesis of N1-Modified Imidazoquinoline Agonists for Selective Activation of Toll-like Receptors 7 and 8.
Larson P, Kucaba TA, Xiong Z, Olin M, Griffith TS, Ferguson DM.
ACS Med Chem Lett. 2017 Oct 16;8(11):1148-1152. doi: 10.1021/acsmedchemlett.7b00256. eCollection 2017 Nov 9.
PMID: 29152046

Hemodynamic Forces Sculpt Developing Heart Valves through a KLF2-WNT9B Paracrine Signaling Axis.
Goddard LM, Duchemin AL, Ramalingan H, Wu B, Chen M, Bamezai S, Yang J, Li L, Morley MP, Wang T, Scherrer-Crosbie M, Frank DB, Engleka KA, Jameson SC, Morrisey EE, Carroll TJ, Zhou B, Vermot J, Kahn ML.
Dev Cell. 2017 Oct 13. pii: S1534-5807(17)30782-7. doi: 10.1016/j.devcel.2017.09.023. [Epub ahead of print]
PMID: 29056552

Defining total-body AIDS-virus burden with implications for curative strategies.
Estes JD, Kityo C, Ssali F, Swainson L, Makamdop KN, Del Prete GQ, Deeks SG, Luciw PA, Chipman JG, Beilman GJ, Hoskuldsson T, Khoruts A, Anderson J, Deleage C, Jasurda J, Schmidt TE, Hafertepe M, Callisto SP, Pearson H, Reimann T, Schuster J, Schoephoerster J, Southern P, Perkey K, Shang L, Wietgrefe SW, Fletcher CV, Lifson JD, Douek DC, McCune JM, Haase AT, Schacker TW.
Nat Med. 2017 Oct 2. doi: 10.1038/nm.4411. [Epub ahead of print]
PMID:28967921

Breast cancer cell-derived fibroblast growth factors enhance osteoclast activity and contribute to the formation of metastatic lesions.
Aukes K, Forsman C, Brady NJ, Astleford K, Blixt N, Sachdev D, Jensen ED, Mansky KC, Schwertfeger KL.
PLoS One. 2017 Oct 2;12(10):e0185736. doi: 10.1371/journal.pone.0185736. eCollection 2017.
PMID:28968431

Polymicrobial sepsis impairs bystander recruitment of effector cells to infected skin despite optimal sensing and alarming function of skin resident memory CD8 T cells.
Danahy DB, Anthony SM, Jensen IJ, Hartwig SM, Shan Q, Xue HH, Harty JT, Griffith TS, Badovinac VP.
PLoS Pathog. 2017 Sep 14;13(9):e1006569. doi: 10.1371/journal.ppat.1006569. eCollection 2017 Sep.
PMID: 28910403

The synergy between ionizing radiation and immunotherapy in the treatment of prostate cancer.
Sathianathen NJ, Krishna S, Konety BR, Griffith TS.
Immunotherapy. 2017 Sep;9(12):1005-1018. doi: 10.2217/imt-2017-0051.
PMID: 28971750

TRAIL Deletion Prevents Liver, but Not Adipose Tissue, Inflammation during Murine Diet-Induced Obesity.
Hirsova P, Weng P, Salim W, Bronk SF, Griffith TS, Ibrahim SH, Gores GJ.
Hepatol Commun. 2017 Sep;1(7):648-662. doi: 10.1002/hep4.1069. Epub 2017 Jul 20.
PMID: 29124251

Landscape review of current HIV 'kick and kill' cure research - some kicking, not enough killing.
Thorlund K, Horwitz MS, Fife BT, Lester R, Cameron DW.
BMC Infect Dis. 2017 Aug 29;17(1):595. doi: 10.1186/s12879-017-2683-3. Review.
PMID: 28851294

Directing T cell fate: How thymic antigen presenting cells coordinate thymocyte selection.
Breed ER, Lee ST, Hogquist KA.
Semin Cell Dev Biol. 2017 Aug 9. pii: S1084-9521(16)30452-9. doi: 10.1016/j.semcdb.2017.07.045. [Epub ahead of print] Review.
PMID: 28800929

STAT5 deletion in macrophages alters ductal elongation and branching during mammary gland development.
Brady NJ, Farrar MA, Schwertfeger KL.
Dev Biol. 2017 Aug 1;428(1):232-244. doi: 10.1016/j.ydbio.2017.06.007. Epub 2017 Jun 9
PMID: 28606561

Stable engraftment of human microbiota into mice with a single oral gavage following antibiotic conditioning.
Staley C, Kaiser T, Beura LK, Hamilton MJ, Weingarden AR, Bobr A, Kang J, Masopust D, Sadowsky MJ, Khoruts A.
Microbiome. 2017 Aug 1;5(1):87. doi: 10.1186/s40168-017-0306-2.
PMID:28760163 

Corrigendum: Spontaneous partial loss of the OT-I transgene.
Pritchard GH, Cross EW, Strobel M, Jameson SC, Kedl RM, Hogquist KA, Hunter CA.
Nat Immunol. 2017 Jul 19;18(8):951. doi: 10.1038/ni0817-951b. No abstract available.
PMID:28722721

Immunologic response to vaccine challenge in pregnant PTPN22 R620W carriers and non-carriers.
Tien SH, Crabtree JN, Gray HL, Peterson EJ.
PLoS One. 2017 Jul 19;12(7):e0181338. doi: 10.1371/journal.pone.0181338. eCollection 2017.
PMID: 28723925 

Identification of Natural Regulatory T Cell Epitopes Reveals Convergence on a Dominant Autoantigen.
Leonard JD, Gilmore DC, Dileepan T, Nawrocka WI, Chao JL, Schoenbach MH, Jenkins MK, Adams EJ, Savage PA.
Immunity. 2017 Jul 18;47(1):107-117.e8. doi: 10.1016/j.immuni.2017.06.015. Epub 2017 Jul 11.
PMID: 28709804

Of Mice, Dirty Mice, and Men: Using Mice To Understand Human Immunology.
Masopust D, Sivula CP, Jameson SC.
J Immunol. 2017 Jul 15;199(2):383-388. doi: 10.4049/jimmunol.1700453. Review.
PMID: 28696328

Tissue-resident memory T cells live off the fat of the land.
Stolley JM, Masopust D.
Cell Res. 2017 Jul;27(7):847-848. doi: 10.1038/cr.2017.49. Epub 2017 Mar 31
PMID: 28361896

CD8αα intraepithelial lymphocytes arise from two main thymic precursors.
Ruscher R, Kummer RL, Lee YJ, Jameson SC, Hogquist KA.
Nat Immunol. 2017 Jul;18(7):771-779. doi: 10.1038/ni.3751. Epub 2017 May 22.
PMID: 28530714

Cytokine-mediated activation of human ex vivo-expanded Vγ9Vδ2 T cells.
Domae E, Hirai Y, Ikeo T, Goda S, Shimizu Y.
Oncotarget. 2017 Jul 11;8(28):45928-45942. doi: 10.18632/oncotarget.17498.
PMID:28521284

Combination therapeutics of Nilotinib and radiation in acute lymphoblastic leukemia as an effective method against drug-resistance.
Kaveh K, Takahashi Y, Farrar MA, Storme G, Guido M, Piepenburg J, Penning J, Foo J, Leder KZ, Hui SK.
PLoS Comput Biol. 2017 Jul 6;13(7):e1005482. doi: 10.1371/journal.pcbi.1005482. eCollection 2017 Jul.
PMID:28683103 

Cutting Edge: Dual TCRα Expression Poses an Autoimmune Hazard by Limiting Regulatory T Cell Generation.
Schuldt NJ, Auger JL, Spanier JA, Martinov T, Breed ER, Fife BT, Hogquist KA, Binstadt BA.
J Immunol. 2017 Jul 1;199(1):33-38. doi: 10.4049/jimmunol.1700406. Epub 2017 May 24.
PMID: 28539428

Constitutive activation of alternative nuclear factor kappa B pathway in canine diffuse large B-cell lymphoma contributes to tumor cell survival and is a target of new adjuvant therapies.
Seelig DM, Ito D, Forster CL, Yoon UA, Breen M, Burns LJ, Bachanova V, Lindblad-Toh K, O'Brien TD, Schmechel SC, Rizzardi AE, Modiano JF, Linden MA.
Leuk Lymphoma. 2017 Jul;58(7):1702-1710. doi: 10.1080/10428194.2016.1260122. Epub 2016 Dec 8.
PMID: 27931134

Interactions between CXCR4 and CXCL12 promote cell migration and invasion of canine hemangiosarcoma.
Im KS, Graef AJ, Breen M, Lindblad-Toh K, Modiano JF, Kim JH.
Vet Comp Oncol. 2017 Jun;15(2):315-327. doi: 10.1111/vco.12165. Epub 2015 Sep 3. Erratum in: Vet Comp Oncol. 2018 Sep;16(3):416.
PMID: 26337509

Sleeve Gastrectomy Drives Persistent Shifts in the Gut Microbiome.
Jahansouz C, Staley C, Bernlohr DA, Sadowsky MJ, Khoruts A, Ikramuddin S.
Surg Obes Relat Dis. 2017 Jun;13(6):916-924. doi: 10.1016/j.soard.2017.01.003. Epub 2017 Jan 4.
PMID: 28279578

Antagonism of B cell enhancer networks by STAT5 drives leukemia and poor patient survival.
Katerndahl CD, Heltemes-Harris LM, Willette MJ, Henzler CM, Frietze S, Yang R, Schjerven H, Silverstein KA, Ramsey LB, Hubbard G, Wells AD, Kuiper RP, Scheijen B, van Leeuwen FN, Müschen M, Kornblau SM, Farrar MA.
Nat Immunol. 2017 Jun;18(6):694-704. doi: 10.1038/ni.3716. Epub 2017 Apr 3.
PMID: 28369050

Infection Followed by Graft-versus-Host Disease: Pathogenic Role of Antibiotics.
Rashidi A, Khoruts A, Weisdorf DJ.
Biol Blood Marrow Transplant. 2017 Jun;23(6):1038-1039. doi: 10.1016/j.bbmt.2017.02.016. Epub 2017 Feb 28. No abstract available.
PMID:28257799

Successful Resolution of Recurrent Clostridium difficile Infection using Freeze-Dried, Encapsulated Fecal Microbiota; Pragmatic Cohort Study.
Staley C, Hamilton MJ, Vaughn BP, Graiziger CT, Newman KM, Kabage AJ, Sadowsky MJ, Khoruts A.
Am J Gastroenterol. 2017 Jun;112(6):940-947. doi: 10.1038/ajg.2017.6. Epub 2017 Feb 14.
PMID: 28195180

T cell progenitor therapy-facilitated thymopoiesis depends upon thymic input and continued thymic microenvironment interaction.
Smith MJ, Reichenbach DK, Parker SL, Riddle MJ, Mitchell J, Osum KC, Mohtashami M, Stefanski HE, Fife BT, Bhandoola A, Hogquist KA, Holländer GA, Zúñiga-Pflücker JC, Tolar J, Blazar BR.
JCI Insight. 2017 May 18;2(10). pii: 92056. doi: 10.1172/jci.insight.92056. [Epub ahead of print]
PMID:28515359 

Implications of Resident Memory T Cells for Transplantation.
Beura LK, Rosato PC, Masopust D.
Am J Transplant. 2017 May;17(5):1167-1175. doi: 10.1111/ajt.14101. Epub 2016 Dec 9. Review.
PMID: 27804207

Changes in microbial ecology after fecal microbiota transplantation for recurrent C. difficile infection affected by underlying inflammatory bowel disease.
Khanna S, Vazquez-Baeza Y, González A, Weiss S, Schmidt B, Muñiz-Pedrogo DA, Rainey JF 3rd, Kammer P, Nelson H, Sadowsky M, Khoruts A, Farrugia SL, Knight R, Pardi DS, Kashyap PC.
Microbiome. 2017 May 15;5(1):55. doi: 10.1186/s40168-017-0269-3.
PMID:28506317 

Role of bone marrow-derived CD11c+ dendritic cells in systolic overload-induced left ventricular inflammation, fibrosis and hypertrophy.
Wang H, Kwak D, Fassett J, Liu X, Yao W, Weng X, Xu X, Xu Y, Bache RJ, Mueller DL, Chen Y.
Basic Res Cardiol. 2017 May;112(3):25. doi: 10.1007/s00395-017-0615-4. Epub 2017 Mar 27.
PMID: 28349258

Community dynamics drive punctuated engraftment of the fecal microbiome following transplantation using freeze-dried, encapsulated fecal microbiota.
Staley C, Vaughn BP, Graiziger CT, Singroy S, Hamilton MJ, Yao D, Chen C, Khoruts A, Sadowsky MJ.
Gut Microbes. 2017 May 4;8(3):276-288. doi: 10.1080/19490976.2017.1299310. Epub 2017 Feb 28.
PMID:28282270

Analysis of gut microbiota - An ever changing landscape.
Sadowsky MJ, Staley C, Heiner C, Hall R, Kelly CR, Brandt L, Khoruts A.
Gut Microbes. 2017 May 4;8(3):268-275. doi: 10.1080/19490976.2016.1277313. Epub 2017 Jan 4.
PMID: 28051919

Fecal Microbiota Transplantation - Early Steps on a Long Journey Ahead.
Khoruts A.
Gut Microbes. 2017 May 4;8(3):199-204. doi: 10.1080/19490976.2017.1316447. Epub 2017 Apr 10. No abstract available.
PMID: 28394706

Treatment of recurrent Clostridium difficile infection using fecal microbiota transplantation in patients with inflammatory bowel disease.
Newman KM, Rank KM, Vaughn BP, Khoruts A.
Gut Microbes. 2017 May 4;8(3):303-309. doi: 10.1080/19490976.2017.1279377. Epub 2017 Jan 19.
PMID: 28102756

Role of bone marrow-derived CD11c+ dendritic cells in systolic overload-induced left ventricular inflammation, fibrosis and hypertrophy.
Wang H, Kwak D, Fassett J, Liu X, Yao W, Weng X, Xu X, Xu Y, Bache RJ, Mueller DL, Chen Y.
Basic Res Cardiol. 2017 May;112(3):25. doi: 10.1007/s00395-017-0615-4. Epub 2017 Mar 27.
PMID: 28349258

Safe and Effective Sarcoma Therapy through Bispecific Targeting of EGFR and uPAR.
Borgatti A, Koopmeiners JS, Sarver AL, Winter AL, Stuebner K, Todhunter D, Rizzardi AE, Henriksen JC, Schmechel S, Forster CL, Kim JH, Froelich J, Walz J, Henson MS, Breen M, Lindblad-Toh K, Oh F, Pilbeam K, Modiano JF, Vallera DA.
Mol Cancer Ther. 2017 May;16(5):956-965. doi: 10.1158/1535-7163.MCT-16-0637. Epub 2017 Feb 13.
PMID: 28193671

Synthesis and Biological Evaluation of Bile Acid Analogues Inhibitory to Clostridium difficile Spore Germination.
Stoltz KL, Erickson R, Staley C, Weingarden AR, Romens E, Steer CJ, Khoruts A, Sadowsky MJ, Dosa PI.
J Med Chem. 2017 Apr 27;60(8):3451-3471. doi: 10.1021/acs.jmedchem.7b00295. Epub 2017 Apr 12.
PMID: 28402634

Antigen-Presenting Cells in the Skin.
Kashem SW, Haniffa M, Kaplan DH.
Annu Rev Immunol. 2017 Apr 26;35:469-499. doi: 10.1146/annurev-immunol-051116-052215. Epub 2017 Feb 6.
PMID: 28226228

A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies.
Murphy KA, James BR, Wilber A, Griffith TS.
J Vis Exp. 2017 Apr 12;(122). doi: 10.3791/55080.
PMID: 28448047

Do Memory B Cells Form Secondary Germinal Centers? It Depends.
Pape KA, Jenkins MK.
Cold Spring Harb Perspect Biol. 2017 Mar 20. pii: a029116. doi: 10.1101/cshperspect.a029116. [Epub ahead of print]
PMID: 28320756

Tissue resident memory T cells and viral immunity.
Rosato PC, Beura LK, Masopust D.
Curr Opin Virol. 2017 Feb;22:44-50. doi: 10.1016/j.coviro.2016.11.011. Epub 2016 Dec 14. Review.
PMID: 27987416

Different Lymphocyte Populations Direct Dichotomous Eosinophil or Neutrophil Responses to Pulmonary Cryptococcus Infection.
Wiesner DL, Smith KD, Kashem SW, Bohjanen PR, Nielsen K.
J Immunol. 2017 Feb 15;198(4):1627-1637. doi: 10.4049/jimmunol.1600821. 
PMID: 28069805

Repeated hapten exposure induces persistent tactile sensitivity in mice modeling localized provoked vulvodynia.
Landry J, Martinov T, Mengistu H, Dhanwada J, Benck CJ, Kline J, Boo B, Swanson L, Tonc E, Daughters R, Fife BT, Chatterjea D.
PLoS One. 2017 Feb 3;12(2):e0169672. doi: 10.1371/journal.pone.0169672.
PMID: 28158195

Gut-sparing treatment of urinary tract infection in patients at high risk of Clostridium difficile infection.
Staley C, Vaughn BP, Graiziger CT, Sadowsky MJ, Khoruts A.
J Antimicrob Chemother. 2017 Feb;72(2):522-528. doi: 10.1093/jac/dkw499. 
PMID: 27999027

Cutting Edge: Adenosine A2a Receptor Signals Inhibit Germinal Center T Follicular Helper Cell Differentiation during the Primary Response to Vaccination.
Schmiel SE, Yang JA, Jenkins MK, Mueller DL.
J Immunol. 2017 Jan 15;198(2):623-628. doi: 10.4049/jimmunol.1601686.
PMID: 27986907

STAT5 and CD4 + T Cell Immunity.
Owen DL, Farrar MA.
F1000Res. 2017 Jan 11;6:32. doi: 10.12688/f1000research.9838.1. Review.
PMID:28163905

Retrieving short-term memories of flu.
Borges da Silva H, Jameson SC.
Sci Immunol. 2017 Jan 6;2(7). pii: eaam5330. doi: 10.1126/sciimmunol.aam5330. Epub 2017 Jan 6. Review.
PMID:28783668

Identification of MHC-Bound Peptides from Dendritic Cells Infected with Salmonella enterica Strain SL1344: Implications for a Nontyphoidal Salmonella Vaccine.
Karunakaran KP, Yu H, Jiang X, Chan Q, Goldberg MF, Jenkins MK, Foster LJ, Brunham RC.
J Proteome Res. 2017 Jan 6;16(1):298-306. doi: 10.1021/acs.jproteome.6b00926. Epub 2016 Nov 10.
PMID: 27802388

Toward revision of antimicrobial therapies in hematopoietic stem cell transplantation: target the pathogens, but protect the indigenous microbiota.
Khoruts A, Hippen KL, Lemire AM, Holtan SG, Knights D, Young JH.
Transl Res. 2017 Jan;179:116-125. doi: 10.1016/j.trsl.2016.07.013. Review.
PMID: 27513211

Interaction of gut microbiota with bile acid metabolism and its influence on disease states.
Staley C, Weingarden AR, Khoruts A, Sadowsky MJ.
Appl Microbiol Biotechnol. 2017 Jan;101(1):47-64. doi: 10.1007/s00253-016-8006-6. Review.
PMID: 27888332

Gene Expression Profiling in Blood and Affected Muscle Tissues Reveals Differential Activation Pathways in Patients with New-onset Juvenile and Adult Dermatomyositis.
López De Padilla CM, Crowson CS, Hein MS, Pendegraft RS, Strausbauch MA, Niewold TB, Ernste FC, Peterson E, Baechler EC, Reed AM.
J Rheumatol. 2017 Jan;44(1):117-124. doi: 10.3899/jrheum.160293.
PMID: 27803134

Enteric immunity, the gut microbiome, and sepsis: Rethinking the germ theory of disease.
Cabrera-Perez J, Badovinac VP, Griffith TS.
Exp Biol Med (Maywood). 2017 Jan;242(2):127-139. doi: 10.1177/1535370216669610. Epub 2016 Oct 4. Review.
PMID: 27633573