2022 Publications
Novel Lymphocytic Choriomeningitis Virus Strain Sustains Abundant Exhausted Progenitor CD8 T Cells without Systemic Viremia.
J Immunol. 2022 Nov 1;209(9):1691-1702. doi: 10.4049/jimmunol.2200320. Epub 2022 Sep 19.
PMID: 36122933
Responsiveness to interleukin-15 therapy is shared between tissue-resident and circulating memory CD8+ T cell subsets.
Jarjour NN, Wanhainen KM, Peng C, Gavil NV, Maurice NJ, Borges da Silva H, Martinez RJ, Dalzell TS, Huggins MA, Masopust D, Hamilton SE, Jameson SC.
Proc Natl Acad Sci U S A. 2022 Oct 25;119(43):e2209021119. doi: 10.1073/pnas.2209021119. Epub 2022 Oct 19.
PMID: 36260745
Reduced T Cell Priming in Microbially Experienced "Dirty" Mice Results from Limited IL-27 Production by XCR1+ Dendritic Cells.
J Immunol. 2022 Oct 17:ji2200324. doi: 10.4049/jimmunol.2200324. Online ahead of print.
PMID: 36253051
Advancing humanized monoclonal antibody for counteracting fentanyl toxicity towards clinical development.
Hum Vaccin Immunother. 2022 Oct 4:2122507. doi: 10.1080/21645515.2022.2122507. Online ahead of print.
PMID: 36194773
Tracking Regulatory T Cell Development in the Thymus Using Single-Cell RNA Sequencing/TCR Sequencing.
J Immunol. 2022 Oct 1;209(7):1300-1313. doi: 10.4049/jimmunol.2200089. Epub 2022 Aug 29.
PMID: 36038290
The B side of B cells in NAFLD.
Hepatology. 2022 Oct;76(4):914-916. doi: 10.1002/hep.32481. Epub 2022 Apr 7.
PMID: 35340064
Cancer Immunol Immunother. 2022 Oct;71(10):2577-2579. doi: 10.1007/s00262-022-03168-7.
PMID: 35179625
Editorial: Immune mechanisms of inflammation in NASH.
Front Endocrinol (Lausanne). 2022 Sep 21;13:1039238. doi: 10.3389/fendo.2022.1039238. eCollection 2022.
PMID: 36213275
Effectiveness and Safety of Colonic and Capsule Fecal Microbiota Transplantation for Recurrent Clostridioides difficile Infection.
Clin Gastroenterol Hepatol. 2022 Sep 17:S1542-3565(22)00880-1. doi: 10.1016/j.cgh.2022.09.008. Online ahead of print.
PMID: 36126907
Non-criteria antiphospholipid antibodies and pediatric rheumatic disease: a case series.
Pediatr Rheumatol Online J. 2022 Aug 20;20(1):70. doi: 10.1186/s12969-022-00732-4.
PMID: 35987646
Functional virus-specific memory T cells survey glioblastoma.
Cancer Immunol Immunother. 2022 Aug;71(8):1863-1875. doi: 10.1007/s00262-021-03125-w. Epub 2022 Jan 10.
PMID: 35001153
Natural Killer Cell Antibody-Dependent Cellular Cytotoxicity (ADCC) Activity Against Plasmodium falciparum-Infected Red Blood Cells.
Methods Mol Biol. 2022;2470:641-657. doi: 10.1007/978-1-0716-2189-9_48.
PMID: 35881380
Type 2 cytokines in the thymus activate Sirpα+ dendritic cells to promote clonal deletion.
Nat Immunol. 2022 Jul;23(7):1042-1051. doi: 10.1038/s41590-022-01218-x. Epub 2022 May 30.
PMID: 35637352
Targeted sequencing of candidate gene regions for myelofibrosis in dogs.
J Vet Intern Med. 2022 Jul;36(4):1237-1247. doi: 10.1111/jvim.16476. Epub 2022 Jul 11.
PMID: 35815881
Immune tolerance of food is mediated by layers of CD4+ T cell dysfunction.
Hong SW, Krueger PD, Osum KC, Dileepan T, Herman A, Mueller DL, Jenkins MK.
Nature. 2022 Jul;607(7920):762-768. doi: 10.1038/s41586-022-04916-6. Epub 2022 Jul 6.
PMID: 35794484
Retinoic acid signaling acts as a rheostat to balance Treg function.
Cell Mol Immunol. 2022 Jul;19(7):820-833. doi: 10.1038/s41423-022-00869-y. Epub 2022 May 17.
PMID: 35581350
Combining nilotinib and PD-L1 blockade reverses CD4+ T-cell dysfunction and prevents relapse in acute B-cell leukemia.
Blood. 2022 Jul 28;140(4):335-348. doi: 10.1182/blood.2021015341.
PMID: 35275990
An OGT-STAT5 Axis in Regulatory T Cells Controls Energy and Iron Metabolism.
Zhang Z, Salgado OC, Liu B, Moazzami Z, Hogquist KA, Farrar MA, Ruan HB.
Front Immunol. 2022 Jul 8;13:874863. doi: 10.3389/fimmu.2022.874863. eCollection 2022.
PMID: 35874700
P2RX7 Enhances Tumor Control by CD8+ T Cells in Adoptive Cell Therapy.
Cancer Immunol Res. 2022 Jul 1;10(7):871-884. doi: 10.1158/2326-6066.CIR-21-0691.
PMID: 35588154
Boosting corrects a memory B cell defect in SARS-CoV-2 mRNA-vaccinated patients with inflammatory bowel disease.
JCI Insight. 2022 Jun 22;7(12):e159618. doi: 10.1172/jci.insight.159618.
PMID: 35730567
Single-cell characterization of step-wise acquisition of carboplatin resistance in ovarian cancer.
NPJ Syst Biol Appl. 2022 Jun 17;8(1):20. doi: 10.1038/s41540-022-00230-z.
PMID: 35715421
CD47 Promotes Autoimmune Valvular Carditis by Impairing Macrophage Efferocytosis and Enhancing Cytokine Production.
J Immunol. 2022 Jun 15;208(12):2643-2651. doi: 10.4049/jimmunol.2100903. Epub 2022 Jun 3.
PMID: 35867674
Unravelling the sex-specific diversity and functions of adrenal gland macrophages.
Cell Rep. 2022 Jun 14;39(11):110949. doi: 10.1016/j.celrep.2022.110949.
PMID: 35705045
Macrophage Fate Mapping.
Curr Protoc. 2022 Jun;2(6):e456. doi: 10.1002/cpz1.456.
PMID: 35687806
Differential hydrogen sulfide production by a human cohort in response to animal- and plant-based diet interventions.
Clin Nutr. 2022 Jun;41(6):1153-1162. doi: 10.1016/j.clnu.2022.03.028. Epub 2022 Apr 5.
PMID: 35500315
Embracing the heterogeneity of natural viruses in mouse studies.
J Gen Virol. 2022 Jun;103(6). doi: 10.1099/jgv.0.001758.PMID: 35737518
Parabiosis in Mice to Study Tissue Residency of Immune Cells.
Curr Protoc. 2022 May;2(5):e446. doi: 10.1002/cpz1.446.
PMID: 35612420
Respiratory Influenza Virus Infection Causes Dynamic Tuft Cell and Innate Lymphoid Cell Changes in the Small Intestine.
J Virol. 2022 May 11;96(9):e0035222. doi: 10.1128/jvi.00352-22. Epub 2022 Apr 21
PMID: 35446142
Preclinical Efficacy and Selectivity of Vaccines Targeting Fentanyl, Alfentanil, Sufentanil, and Acetylfentanyl in Rats.
ACS Omega. 2022 May 4;7(19):16584-16592. doi: 10.1021/acsomega.2c00820. eCollection 2022 May 17.
PMID: 35601290
Comparative analysis of genome-wide DNA methylation identifies patterns that associate with conserved transcriptional programs in osteosarcoma.
Bone. 2022 May;158:115716. doi: 10.1016/j.bone.2020.115716. Epub 2020 Oct 27.
PMID: 33127576
γδ Thymocyte Maturation and Emigration in Adult Mice.
J Immunol. 2022 May 1;208(9):2131-2140. doi: 10.4049/jimmunol.2100360. Epub 2022 Apr 8.
PMID: 35396221
Gut microbial β-glucuronidases regulate host luminal proteases and are depleted in irritable bowel syndrome.
Nat Microbiol. 2022 May;7(5):680-694. doi: 10.1038/s41564-022-01103-1. Epub 2022 Apr 28.
PMID: 35484230
Respiratory Influenza Virus Infection Causes Dynamic Tuft Cell and Innate Lymphoid Cell Changes in the Small Intestine.
J Virol. 2022 May 11;96(9):e0035222. doi: 10.1128/jvi.00352-22. Epub 2022 Apr 21.
PMID: 35446142
Pharmacological Profiling of Antifentanyl Monoclonal Antibodies in Combination with Naloxone in Pre- and Postexposure Models of Fentanyl Toxicity.
J Pharmacol Exp Ther. 2022 May;381(2):129-136. doi: 10.1124/jpet.121.001048. Epub 2022 Feb 13.
PMID: 35153198
A dominant function of LynB kinase in preventing autoimmunity.
Sci Adv. 2022 Apr 22;8(16):eabj5227. doi: 10.1126/sciadv.abj5227. Epub 2022 Apr 22.
PMID: 35452291
Efficacy and Selectivity of Monovalent and Bivalent Vaccination Strategies to Protect against Exposure to Carfentanil, Fentanyl, and Their Mixtures in Rats.
ACS Pharmacol Transl Sci. 2022 Apr 20;5(5):331-343. doi: 10.1021/acsptsci.1c00260. eCollection 2022 May 13.
PMID: 35592436
Brown adipose tissue involution associated with progressive restriction in progenitor competence.
Huang Z, Zhang Z, Moazzami Z, Heck R, Hu P, Nanda H, Ren K, Sun Z, Bartolomucci A, Gao Y, Chung D, Zhu W, Shen S, Ruan HB.
Cell Rep. 2022 Apr 12;39(2):110575. doi: 10.1016/j.celrep.2022.110575.
PMID: 35417710
The Conundrum of Lung Disease and Drug Hypersensitivity-like Reactions in Systemic Juvenile Idiopathic Arthritis.
Arthritis Rheumatol. 2022 Apr 12. doi: 10.1002/art.42137. Online ahead of print.
PMID: 35413159
Epithelial STAT6 O-GlcNAcylation drives a concerted anti-helminth alarmin response dependent on tuft cell hyperplasia and Gasdermin C.
Immunity. 2022 Apr 12;55(4):623-638.e5. doi: 10.1016/j.immuni.2022.03.009. Epub 2022 Apr 5.PMID: 35385697
Distinct myeloid antigen-presenting cells dictate differential fates of tumor-specific CD8+ T cells in pancreatic cancer.
JCI Insight. 2022 Apr 8;7(7):e151593. doi: 10.1172/jci.insight.151593.
PMID: 35393950
SH3-domain mutations selectively disrupt Csk homodimerization or PTPN22 binding.
Sci Rep. 2022 Apr 7;12(1):5875. doi: 10.1038/s41598-022-09589-9.
PMID: 35393453
Differential hydrogen sulfide production by a human cohort in response to animal- and plant-based diet interventions.
Clin Nutr. 2022 Apr 5;41(6):1153-1162. doi: 10.1016/j.clnu.2022.03.028. Online ahead of print.
PMID: 35500315
The Extracellular ATP Receptor P2RX7 Imprints a Promemory Transcriptional Signature in Effector CD8+ T Cells.
J Immunol. 2022 Apr 1;208(7):1686-1699. doi: 10.4049/jimmunol.2100555. Epub 2022 Mar 9.
PMID: 35264459
Glucosamine facilitates cardiac ischemic recovery via recruiting Ly6Clow monocytes in a STAT1 and O-GlcNAcylation-dependent fashion.
Clin Transl Med. 2022 Mar;12(3):e762. doi: 10.1002/ctm2.762.
PMID: 35343077
Toll-like Receptor 7 and 8 Imidazoquinoline-Based Agonist/Antagonist Pairs.
Bioorg Med Chem Lett. 2022 Mar 1;59:128548. doi: 10.1016/j.bmcl.2022.128548. Epub 2022 Jan 18.
PMID: 35051578
Examination of IgG Fc Receptor CD16A and CD64 Expression by Canine Leukocytes and Their ADCC Activity in Engineered NK Cells.
Front Immunol. 2022 Feb 24;13:841859. doi: 10.3389/fimmu.2022.841859. eCollection 2022.
PMID: 35281028
Redox regulation of age-associated defects in generation and maintenance of T cell self-tolerance and immunity to foreign antigens.
Hester AK, Semwal MK, Cepeda S, Xiao Y, Rueda M, Wimberly K, Venables T, Dileepan T, Kraig E, Griffith AV.
Cell Rep. 2022 Feb 15;38(7):110363. doi: 10.1016/j.celrep.2022.110363.
PMID: 35172147
Insufficiency of compound immune checkpoint blockade to overcome engineered T cell exhaustion in pancreatic cancer.
J Immunother Cancer. 2022 Feb;10(2):e003525. doi: 10.1136/jitc-2021-003525.
PMID: 35210305
Characterization of influenza A virus induced transposons reveals a subgroup of transposons likely possessing the regulatory role as eRNAs.
Sci Rep. 2022 Feb 9;12(1):2188. doi: 10.1038/s41598-022-06196-6.
PMID: 35140280
Natural rodent model of viral transmission reveals biological features of virus population dynamics.
Fay EJ, Balla KM, Roach SN, Shepherd FK, Putri DS, Wiggen TD, Goldstein SA, Pierson MJ, Ferris MT, Thefaine CE, Tucker A, Salnikov M, Cortez V, Compton SR, Kotenko SV, Hunter RC, Masopust D, Elde NC, Langlois RA.
J Exp Med. 2022 Feb 7;219(2):e20211220. doi: 10.1084/jem.20211220. Epub 2021 Dec 27.
PMID: 34958350
Lung-resident memory B cells established after pulmonary influenza infection display distinct transcriptional and phenotypic profiles.
Sci Immunol. 2022 Jan 28;7(67):eabf5314. doi: 10.1126/sciimmunol.abf5314. Epub 2022 Jan 28.
PMID: 35089815
Engagement of the costimulatory molecule ICOS in tissues promotes establishment of CD8+ tissue-resident memory T cells.
Peng C, Huggins MA, Wanhainen KM, Knutson TP, Lu H, Georgiev H, Mittelsteadt KL, Jarjour NN, Wang H, Hogquist KA, Campbell DJ, Borges da Silva H, Jameson SC.
Immunity. 2022 Jan 11;55(1):98-114.e5. doi: 10.1016/j.immuni.2021.11.017. Epub 2021 Dec 20.
PMID: 34932944
Sphingosine 1-phosphate receptor 5 (S1PR5) regulates the peripheral retention of tissue-resident lymphocytes.
Evrard M, Wynne-Jones E, Peng C, Kato Y, Christo SN, Fonseca R, Park SL, Burn TN, Osman M, Devi S, Chun J, Mueller SN, Kannourakis G, Berzins SP, Pellicci DG, Heath WR, Jameson SC, Mackay LK.
J Exp Med. 2022 Jan 3;219(1):e20210116. doi: 10.1084/jem.20210116. Epub 2021 Oct 22.
PMID: 34677611