The Center for Immunology produces an immense amount of research each year.  The data produced is comprehensive and timely to research across the globe.  Our research is supported by Government, Commercial and Industrial grants and private funds and is produced in our state of the art research facilities.  The research is carried out by faculty members, visiting scholars, post-doctoral fellows, graduate, and undergraduate students and technicians. The Center for Immunology also has a strong collaboration history with colleagues at other Universities and research companies worldwide.

To honor the Center for Immunology faculty with 200 or more citations on one paper we have created our wall of honor.

Wall of Honor (500+ citations)

Interferon-inducible gene expression signature in peripheral blood cells of patients with severe lupus.
Baechler EC, Batliwalla FM, Karypis G, Gaffney PM, Ortmann WA, Espe KJ, Shark KB, Grande WJ, Hughes KM, Kapur V, Gregersen PK, Behrens TW.
Proc Natl Acad Sci U S A. 2003 Mar 4;100(5):2610-5. PMID: 12604793   
Published: March 4, 2003

Visualizing the generation of memory CD4 T cells in the whole body 
Reinhardt, RL; Khoruts, A; Merica, R; Zell, T; Jenkins MK.
NATURE  Volume: 410   Issue: 6824   Pages: 101-105   
Published: March 1, 2001

Naive CD4(+) T cell frequency varies for different epitopes and predicts repertoire diversity and response magnitude 
Moon, James J.; Chu HH, Pepper M, McSorley SJ, Jameson SC, Kedl RM, Jenkins MK.
IMMUNITY  Volume: 27   Issue: 2   Pages: 203-213   
Published: August 2007

T cell receptor signal strength in Treg and iNKT cell development demonstrated by a novel fluorescent reporter mouse.
Moran AE, Holzapfel KL, Xing Y, Cunningham NR, Maltzman JS, Punt J, Hogquist KA.
JOURNAL OF EXPERIMENTAL MEDICINE  Volume 208  Issue 6  Pages: 1279-1289  
Published: June 6, 2011

IL-2 receptor beta-dependent STAT5 activation is required for the development of Foxp3(+) regulatory T cells 
Burchill, M; Yang J, Vogtenhuber C, Blazar BR, Farrar MA.
JOURNAL OF IMMUNOLOGY  Volume: 178   Issue: 1  Pages: 280-290   
Published: January 1, 2007

Normalizing the environment recapitulates adult human immune traits in laboratory mice.
Beura LK, Hamilton SE, Bi K, Schenkel JM, Odumade OA, Casey KA, Thompson EA, Fraser KA, Rosato PC, Filali-Mouhim A, Sekaly RP, Jenkins MK, Vezys V, Haining WN, Jameson SC, Masopust D.
Nature. 2016 Apr 28;532(7600):512-6. doi: 10.1038/nature17655.
PMID: 27096360 
Published April 28, 2016

Dynamic T cell migration program provides resident memory within intestinal epithelium.
Masopust D, Choo D, Vezys V, Wherry EJ, Duraiswamy J, Akondy R, Wang J, Casey KA, Barber DL, Kawamura KS, Fraser KA, Webby RJ, Brinkmann V, Butcher EC, Newell KA, Ahmed R.
J Exp Med. 2010 Mar 15;207(3):553-64. doi: 10.1084/jem.20090858.
PMID: 20156972 
Published: March 15, 2010

Visualization of specific B and T lymphocyte interactions in the lymph node 
Garside P, Ingulli E, Merica RR, Johnson JG, Noelle RJ, Jenkins MK.
SCIENCE  Volume: 281   Issue: 5373   Pages: 96-99   
Published: July 3, 1998

Interactions between PD-1 and PD-L1 promote tolerance by blocking the TCR-induced stop signal 
Fife, B; Pauken KE, Eagar TN, Obu T, Wu J, Tang Q, Azuma M, Krummel MF, Bluestone JA.
NATURE IMMUNOLOGY  Volume: 10   Issue: 11   Pages: 1185-U70   
Published: November 2009

Distinct dendritic cell populations sequentially present antigen to CD4 T cells and stimulate different aspects of cell-mediated immunity 
Itano, AA; McSorley SJ, Reinhardt RL, Ehst BD, Ingulli E, Rudensky AY, Jenkins MK.
IMMUNITY  Volume: 19   Issue: 1  Pages: 47-57  
Published: July 2003

Wall of Honor (200+ citations)

Thymic emigration revisited. 
McCaughtry TM, Wilken MS, Hogquist KA.
J Exp Med. 2007 Oct 29;204(11):2513-20. doi: 10.1084/jem.20070601. Epub 2007 Oct 1. PMID: 17908937
Published: October 29, 2007

Costimulation via the tumor-necrosis factor receptor superfamily couples TCR signal strength to the thymic differentiation of regulatory T cells. 
Mahmud SA, Manlove LS, Schmitz HM, Xing Y, Wang Y, Owen DL, Schenkel JM, Boomer JS, Green JM, Yagita H, Chi H, Hogquist KA, Farrar MA. 
Nat Immunol. 2014 May;15(5):473-81. doi: 10.1038/ni.2849. PMID: 24633226
Published: May 1, 2014

Standardized frozen preparation for transplantation of fecal microbiota for recurrent Clostridium difficile infection.
Hamilton MJ, Weingarden AR, Sadowsky MJ, Khoruts A.
Am J Gastroenterol. 2012 May;107(5):761-7. doi: 10.1038/ajg.2011.482. PMID: 22290405 
Published: May 2012

Changes in the Composition of the Human Fecal Microbiome After Bacteriotherapy for Recurrent Clostridium difficile-associated Diarrhea 
Khoruts, A; Dicksved J, Jansson JK, Sadowsky MJ.
JOURNAL OF CLINICAL GASTROENTEROLOGY  Volume: 44   Issue: 5   Pages: 354-360  
Published: May-June 2010

Transcriptional downregulation of S1pr1 is required for the establishment of resident memory CD8+ T cells.
Skon CN, Lee JY, Anderson KG, Masopust D, Hogquist KA, Jameson SC.
Nat Immunol. 2013 Dec;14(12):1285-93. doi: 10.1038/ni.2745. Epub 2013 Oct 27. PMID: 24162775 
Published: December 2013

Cutting edge: Type I IFNs provide a third signal to CD8 T cells to stimulate clonal expansion and differentiation 
Curtsinger, JM; Valenzuela JO, Agarwal P, Lins D, Mescher MF.
JOURNAL OF IMMUNOLOGY  Volume: 174   Issue: 8   Pages: 4465-4469   
Published: April 15, 2005

In vivo detection of dendritic cell antigen presentation to CD4(+) T cells 
Ingulli E, Mondino A, Khoruts A, Jenkins MK.
JOURNAL OF EXPERIMENTAL MEDICINE  Volume: 185 Issue: 12 Pages: 2133-2141
Published: June 16, 1997

Quantifying Memory CD8 T Cells Reveals Regionalization of Immunosurveillance.
Steinert EM, Schenkel JM, Fraser KA, Beura LK, Manlove LS, Igyártó BZ, Southern PJ, Masopust D.
Cell. 2015 May 7;161(4):737-49. doi: 10.1016/j.cell.2015.03.031. PMID: 25957682
Published: May 7, 2016

Inflammatory cytokines provide a third signal for activation of naive CD4(+) and CD8(+) T cells 
Curtsinger, JM; Schmidt CS, Mondino A, Lins DC, Kedl RM, Jenkins MK, Mescher MF.
JOURNAL OF IMMUNOLOGY  Volume: 162   Issue: 6   Pages: 3256-3262  
Published: March 15, 1999

T cell memory. Resident memory CD8 T cells trigger protective innate and adaptive immune responses. 
Schenkel JM, Fraser KA, Beura LK, Pauken KE, Vezys V, Masopust D.
Science. 2014 Oct 3;346(6205):98-101. doi: 10.1126/science.1254536. Epub 2014 Aug 28. PMID: 25170049
Published: October 3, 2014

Antigen-independent differentiation and maintenance of effector-like resident memory T cells in tissues.
Casey KA, Fraser KA, Schenkel JM, Moran A, Abt MC, Beura LK, Lucas PJ, Artis D, Wherry EJ, Hogquist K, Vezys V, Masopust D.
J Immunol. 2012 May 15;188(10):4866-75. doi: 10.4049/jimmunol.1200402. Epub 2012 Apr 13. PMID: 22504644. 
Published: May 15, 2012

Sensing and alarm function of resident memory CD8⁺ T cells.
Schenkel JM, Fraser KA, Vezys V, Masopust D.
Nat Immunol. 2013 May;14(5):509-13. doi: 10.1038/ni.2568. Epub 2013 Mar 31. Erratum in: Nat Immunol. 2013 Aug;14(8):876. PMID: 23542740
Published: August 2013

Blocked signal transduction to the ERK and JNKprotein kinases in anergic CD4+ T cells.
Li W, Whaley CD, Mondino A, Mueller DL.
SCIENCE, 1996 Mar 1;271(5253):1272-6. PMID:8638107
Published: March 1, 1996

Steady-state production of IL-4 modulates immunity in mouse strains and is determined by lineage diversity of iNKT cells.
Lee YJ, Holzapfel KL, Zhu J, Jameson SC, Hogquist KA.
Nat Immunol. 2013 Nov;14(11):1146-54. doi: 10.1038/ni.2731. Epub 2013 Oct 6. Erratum in: Nat Immunol. 2014 Mar;15(3):305.PMID:24097110 
Published: March 2014

Signal 3 determines tolerance versus full activation of naive CD8 T cells: Dissociating proliferation and development of effector function 
Curtsinger, JM; Lins, DC; Mescher, MF
JOURNAL OF EXPERIMENTAL MEDICINE  Volume: 197   Issue: 9   Pages: 1141-1151   
Published: May 5, 2003

Identification of a novel population of Langerin(+) dendritic cells 
Bursch, L; Wang L, Igyarto B, Kissenpfennig A, Malissen B, Kaplan DH, Hogquist KA.
JOURNAL OF EXPERIMENTAL MEDICINE  Volume: 204   Issue: 13   Pages: 3147-3156   
Published: December 24, 2007

Different B cell populations mediate early and late memory during an endogenous immune response.
Pape KA, Taylor JJ, Maul RW, Gearhart PJ, Jenkins MK.
Science. 2011 Mar 4;331(6021):1203-7. doi: 10.1126/science.1201730. Epub 2011 Feb 10. PMID:21310965 
Published March 4, 2011

Generation of anergic and potentially immunoregulatory CD25(+)CD4 T cells in vivo after induction of peripheral tolerance with intravenous or oral antigen 
Thorstenson, KM; Khoruts, A
JOURNAL OF IMMUNOLOGY  Volume: 167   Issue: 1  Pages: 188-195   
Published: July 1, 2001

Linked T cell receptor and cytokine signaling govern the development of the regulatory T cell repertoire.
Burchill MA, Yang J, Vang KB, Moon JJ, Chu HH, Lio CW, Vegoe AL, Hsieh CS, Jenkins MK, Farrar MA.
Immunity. 2008 Jan;28(1):112-21. PMID: 18199418   
Published: Jan 18, 2008

Single naive CD4+ T cells from a diverse repertoire produce different effector cell types during infection.
Tubo NJ, Pagán AJ, Taylor JJ, Nelson RW, Linehan JL, Ertelt JM, Huseby ES, Way SS, Jenkins MK.
Cell. 2013 May 9;153(4):785-96. doi: 10.1016/j.cell.2013.04.007. PMID: 23663778
Published: May 9, 2013

Skin-resident murine dendritic cell subsets promote distinct and opposing antigen-specific T helper cell responses.
Igyártó BZ, Haley K, Ortner D, Bobr A, Gerami-Nejad M, Edelson BT, Zurawski SM, Malissen B, Zurawski G, Berman J, Kaplan DH.
Immunity. 2011 Aug 26;35(2):260-72. doi: 10.1016/j.immuni.2011.06.005. Epub 2011 Jul 21. PMID:21782478 
Published: August 26, 2011

Opposing signals from the Bcl6 transcription factor and the Interleukin-2 receptor generate T-helper 1 central and effector memory cells. 
Pepper M, Pagán AJ, Igyártó BZ, Taylor JJ, Jenkins MK.
Immunity. 2011 Oct 28;35(4):583-95. doi: 10.1016/j.immuni.2011.09.009. Epub 2011 Oct 20. PMID: 22018468 
Published October 28, 2011

Homeostatic expansion and phenotypic conversion of naive T cells in response to self-peptide/MHC ligands 
Kieper, WC; Jameson, SC
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA  Volume: 96   Issue: 23  Pages: 13306-13311  
Published: November 9, 1999

Microbiota transplantation restores normal fecal bile acid composition in recurrent Clostridium difficile infection. 
Weingarden AR, Chen C, Bobr A, Yao D, Lu Y, Nelson VM, Sadowsky MJ, Khoruts A.
Am J Physiol Gastrointest Liver Physiol. 2014 Feb 15;306(4):G310-9. doi: 10.1152/ajpgi.00282.2013. Epub 2013 Nov 27.
PMID: 24284963
Published: February 15, 2014

Naive and memory CD4(+) T cell survival controlled by clonal abundance 
Hataye, J; Moon JJ, Khoruts A, Reilly C, Jenkins MK.
SCIENCE  Volume: 312   Issue: 5770   Pages: 114-116   
Published: April 7, 2006

The humoral immune response is initiated in lymph nodes by B cells that acquire soluble antigen directly in the follicles.
Pape KA, Catron DM, Itano AA, Jenkins MK.
Immunity. 2007 Apr;26(4):491-502. Epub 2007 Mar 22. PMID:17379546 
Published: April 27, 2007

CTLA-4 blockade reverses CD8+ T cell tolerance to tumor by a CD4+ T cell- and IL-2-dependent mechanism.
Shrikant P, Khoruts A, Mescher MF.
Immunity. 1999 Oct;11(4):483-93. PMID: 10549630
Published: Oct 1, 1999

Nociceptive Sensory Fibers Drive Interleukin-23 Production from CD301b+ Dermal Dendritic Cells and Drive Protective Cutaneous Immunity.
Kashem SW, Riedl MS, Yao C, Honda CN, Vulchanova L, Kaplan DH.
Immunity. 2015 Sep 15;43(3):515-26. doi: 10.1016/j.immuni.2015.08.016. PMID: 26377898
Published: September 15, 2015

Inflammatory cytokines enhance the in vivo clonal expansion and differentiation of antigen-activated CD4+ T cells.
Pape KA, Khoruts A, Mondino A, Jenkins MK.
J Immunol. 1997 Jul 15;159(2):591-8. 
Published: July 15, 1997