The Center for Immunology produces an immense amount of research each year.  The data produced is comprehensive and timely to research across the globe.  Our research is supported by Government, Commercial and Industrial grants and private funds and is produced in our state of the art research facilities.  The research is carried out by faculty members, visiting scholars, post-doctoral fellows, graduate, and undergraduate students and technicians. The Center for Immunology also has a strong collaboration history with colleagues at other Universities and research companies worldwide.

CFI Wall of Honor

To honor the Center for Immunology faculty with 200 or more citations on one paper we have created our wall of honor.

Wall of Honor (500+ citations)

Interferon-inducible gene expression signature in peripheral blood cells of patients with severe lupus.
Baechler EC, Batliwalla FM, Karypis G, Gaffney PM, Ortmann WA, Espe KJ, Shark KB, Grande WJ, Hughes KM, Kapur V, Gregersen PK, Behrens TW.
Proc Natl Acad Sci U S A. 2003 Mar 4;100(5):2610-5. PMID: 12604793   
Published: March 4, 2003

Visualizing the generation of memory CD4 T cells in the whole body 
Reinhardt, RL; Khoruts, A; Merica, R; Zell, T; Jenkins MK.
NATURE  Volume: 410   Issue: 6824   Pages: 101-105   
Published: March 1, 2001

Naive CD4(+) T cell frequency varies for different epitopes and predicts repertoire diversity and response magnitude 
Moon, James J.; Chu HH, Pepper M, McSorley SJ, Jameson SC, Kedl RM, Jenkins MK.
IMMUNITY  Volume: 27   Issue: 2   Pages: 203-213   
Published: August 2007

T cell receptor signal strength in Treg and iNKT cell development demonstrated by a novel fluorescent reporter mouse.
Moran AE, Holzapfel KL, Xing Y, Cunningham NR, Maltzman JS, Punt J, Hogquist KA.
JOURNAL OF EXPERIMENTAL MEDICINE  Volume 208  Issue 6  Pages: 1279-1289  
Published: June 6, 2011

IL-2 receptor beta-dependent STAT5 activation is required for the development of Foxp3(+) regulatory T cells 
Burchill, M; Yang J, Vogtenhuber C, Blazar BR, Farrar MA.
JOURNAL OF IMMUNOLOGY  Volume: 178   Issue: 1  Pages: 280-290   
Published: January 1, 2007

Normalizing the environment recapitulates adult human immune traits in laboratory mice.
Beura LK, Hamilton SE, Bi K, Schenkel JM, Odumade OA, Casey KA, Thompson EA, Fraser KA, Rosato PC, Filali-Mouhim A, Sekaly RP, Jenkins MK, Vezys V, Haining WN, Jameson SC, Masopust D.
Nature. 2016 Apr 28;532(7600):512-6. doi: 10.1038/nature17655.
PMID: 27096360 
Published April 28, 2016

Dynamic T cell migration program provides resident memory within intestinal epithelium.
Masopust D, Choo D, Vezys V, Wherry EJ, Duraiswamy J, Akondy R, Wang J, Casey KA, Barber DL, Kawamura KS, Fraser KA, Webby RJ, Brinkmann V, Butcher EC, Newell KA, Ahmed R.
J Exp Med. 2010 Mar 15;207(3):553-64. doi: 10.1084/jem.20090858.
PMID: 20156972 
Published: March 15, 2010

Wall of Honor (200+ citations)

Thymic emigration revisited. 
McCaughtry TM, Wilken MS, Hogquist KA.
J Exp Med. 2007 Oct 29;204(11):2513-20. doi: 10.1084/jem.20070601. Epub 2007 Oct 1. PMID: 17908937
Published: October 29, 2007

Costimulation via the tumor-necrosis factor receptor superfamily couples TCR signal strength to the thymic differentiation of regulatory T cells. 
Mahmud SA, Manlove LS, Schmitz HM, Xing Y, Wang Y, Owen DL, Schenkel JM, Boomer JS, Green JM, Yagita H, Chi H, Hogquist KA, Farrar MA. 
Nat Immunol. 2014 May;15(5):473-81. doi: 10.1038/ni.2849. PMID: 24633226
Published: May 1, 2014

Standardized frozen preparation for transplantation of fecal microbiota for recurrent Clostridium difficile infection.
Hamilton MJ, Weingarden AR, Sadowsky MJ, Khoruts A.
Am J Gastroenterol. 2012 May;107(5):761-7. doi: 10.1038/ajg.2011.482. PMID: 22290405 
Published: May 2012

Changes in the Composition of the Human Fecal Microbiome After Bacteriotherapy for Recurrent Clostridium difficile-associated Diarrhea 
Khoruts, A; Dicksved J, Jansson JK, Sadowsky MJ.
JOURNAL OF CLINICAL GASTROENTEROLOGY  Volume: 44   Issue: 5   Pages: 354-360  
Published: May-June 2010

Transcriptional downregulation of S1pr1 is required for the establishment of resident memory CD8+ T cells.
Skon CN, Lee JY, Anderson KG, Masopust D, Hogquist KA, Jameson SC.
Nat Immunol. 2013 Dec;14(12):1285-93. doi: 10.1038/ni.2745. Epub 2013 Oct 27. PMID: 24162775 
Published: December 2013

Cutting edge: Type I IFNs provide a third signal to CD8 T cells to stimulate clonal expansion and differentiation 
Curtsinger, JM; Valenzuela JO, Agarwal P, Lins D, Mescher MF.
JOURNAL OF IMMUNOLOGY  Volume: 174   Issue: 8   Pages: 4465-4469   
Published: April 15, 2005

In vivo detection of dendritic cell antigen presentation to CD4(+) T cells 
Ingulli E, Mondino A, Khoruts A, Jenkins MK.
JOURNAL OF EXPERIMENTAL MEDICINE  Volume: 185 Issue: 12 Pages: 2133-2141
Published: June 16, 1997

Quantifying Memory CD8 T Cells Reveals Regionalization of Immunosurveillance.
Steinert EM, Schenkel JM, Fraser KA, Beura LK, Manlove LS, Igyártó BZ, Southern PJ, Masopust D.
Cell. 2015 May 7;161(4):737-49. doi: 10.1016/j.cell.2015.03.031. PMID: 25957682
Published: May 7, 2016

Inflammatory cytokines provide a third signal for activation of naive CD4(+) and CD8(+) T cells 
Curtsinger, JM; Schmidt CS, Mondino A, Lins DC, Kedl RM, Jenkins MK, Mescher MF.
JOURNAL OF IMMUNOLOGY  Volume: 162   Issue: 6   Pages: 3256-3262  
Published: March 15, 1999

T cell memory. Resident memory CD8 T cells trigger protective innate and adaptive immune responses. 
Schenkel JM, Fraser KA, Beura LK, Pauken KE, Vezys V, Masopust D.
Science. 2014 Oct 3;346(6205):98-101. doi: 10.1126/science.1254536. Epub 2014 Aug 28. PMID: 25170049
Published: October 3, 2014

Antigen-independent differentiation and maintenance of effector-like resident memory T cells in tissues.
Casey KA, Fraser KA, Schenkel JM, Moran A, Abt MC, Beura LK, Lucas PJ, Artis D, Wherry EJ, Hogquist K, Vezys V, Masopust D.
J Immunol. 2012 May 15;188(10):4866-75. doi: 10.4049/jimmunol.1200402. Epub 2012 Apr 13. PMID: 22504644. 
Published: May 15, 2012

Intravascular staining for discrimination of vascular and tissue leukocytes. 
Anderson KG, Mayer-Barber K, Sung H, Beura L, James BR, Taylor JJ, Qunaj L, Griffith TS, Vezys V, Barber DL, Masopust D.
Nat Protoc. 2014 Jan;9(1):209-22. doi: 10.1038/nprot.2014.005. Epub 2014 Jan 2. PMID: 24385150
Published: January 2014

Kruppel-like factor 2 regulates thymocyte and T-cell migration 
Carlson, C; Endrizzi BT, Wu J, Ding X, Weinreich MA, Walsh ER, Wani MA, Lingrel JB, Hogquist KA, Jameson SC.
NATURE  Volume: 442   Issue: 7100   Pages: 299-302   
Published: July 20, 2006

Sensing and alarm function of resident memory CD8⁺ T cells.
Schenkel JM, Fraser KA, Vezys V, Masopust D.
Nat Immunol. 2013 May;14(5):509-13. doi: 10.1038/ni.2568. Epub 2013 Mar 31. Erratum in: Nat Immunol. 2013 Aug;14(8):876. PMID: 23542740
Published: August 2013

A germinal center-independent pathway generates unswitched memory B cells early in the primary response. 
Taylor JJ, Pape KA, Jenkins MK.
J Exp Med. 2012 Mar 12;209(3):597-606. doi: 10.1084/jem.20111696. Epub 2012 Feb 27. PMID: 22370719
Published: March 12, 2012

Different routes of bacterial infection induce long-lived TH1 memory cells and short-lived TH17 cells. 
Pepper M, Linehan JL, Pagán AJ, Zell T, Dileepan T, Cleary PP, Jenkins MK.
Nat Immunol. 2010 Jan;11(1):83-9. doi: 10.1038/ni.1826. Epub 2009 Nov 22. PMID: 19935657
Published: January 2010

Critical role for CD8 in T cell receptor binding and activation by peptide/major histocompatibilitycomplex multimers. 
Daniels MA, Jameson SC.
J Exp Med. 2000 Jan 17;191(2):335-46. PMID:10637277 
Published: January 17, 2017

CD8 T cell clonal expansion and development of effector function require prolonged exposure to antigen, costimulation, and signal 3 cytokine. 
Curtsinger JM, Johnson CM, Mescher MF. J Immunol. 2003 Nov 15;171(10):5165-71. doi: 10.4049/jimmunol.171.10.5165.
PMID: 14607916
Published: November 15, 2003

Cutting edge: intravascular staining redefines lung CD8 T cell responses.
Anderson KG, Sung H, Skon CN, Lefrancois L, Deisinger A, Vezys V, Masopust D.
J Immunol. 2012 Sep 15;189(6):2702-6. doi: 10.4049/jimmunol.1201682. Epub 2012 Aug 15. PMID: 22896631
Published: September 15, 2012

Tracking epitope-specific T cells. 
Moon JJ, Chu HH, Hataye J, Pagán AJ, Pepper M, McLachlan JB, Zell T, Jenkins MK.
Nat Protoc. 2009;4(4):565-81. doi: 10.1038/nprot.2009.9. PMID: 19373228
Published: December 9, 2012