The Center for Immunology produces an immense amount of research each year. The data produced is comprehensive and timely to research across the globe. Our research is supported by Government, Commercial and Industrial grants and private funds and is produced in our state of the art research facilities. The research is carried out by faculty members, visiting scholars, post-doctoral fellows, graduate, and undergraduate students and technicians. The Center for Immunology also has a strong collaboration history with colleagues at other Universities and research companies worldwide.
To honor the Center for Immunology faculty with 200 or more citations on one paper we have created our wall of honor.
Wall of Honor (500+ citations)
Interferon-inducible gene expression signature in peripheral blood cells of patients with severe lupus.
Baechler EC, Batliwalla FM, Karypis G, Gaffney PM, Ortmann WA, Espe KJ, Shark KB, Grande WJ, Hughes KM, Kapur V, Gregersen PK, Behrens TW.
Proc Natl Acad Sci U S A. 2003 Mar 4;100(5):2610-5. PMID: 12604793
Published: March 4, 2003
Visualizing the generation of memory CD4 T cells in the whole body
Reinhardt, RL; Khoruts, A; Merica, R; Zell, T; Jenkins MK.
NATURE Volume: 410 Issue: 6824 Pages: 101-105
Published: March 1, 2001
Naive CD4(+) T cell frequency varies for different epitopes and predicts repertoire diversity and response magnitude
Moon, James J.; Chu HH, Pepper M, McSorley SJ, Jameson SC, Kedl RM, Jenkins MK.
IMMUNITY Volume: 27 Issue: 2 Pages: 203-213
Published: August 2007
T cell receptor signal strength in Treg and iNKT cell development demonstrated by a novel fluorescent reporter mouse.
Moran AE, Holzapfel KL, Xing Y, Cunningham NR, Maltzman JS, Punt J, Hogquist KA.
JOURNAL OF EXPERIMENTAL MEDICINE Volume 208 Issue 6 Pages: 1279-1289
Published: June 6, 2011
IL-2 receptor beta-dependent STAT5 activation is required for the development of Foxp3(+) regulatory T cells
Burchill, M; Yang J, Vogtenhuber C, Blazar BR, Farrar MA.
JOURNAL OF IMMUNOLOGY Volume: 178 Issue: 1 Pages: 280-290
Published: January 1, 2007
Normalizing the environment recapitulates adult human immune traits in laboratory mice.
Beura LK, Hamilton SE, Bi K, Schenkel JM, Odumade OA, Casey KA, Thompson EA, Fraser KA, Rosato PC, Filali-Mouhim A, Sekaly RP, Jenkins MK, Vezys V, Haining WN, Jameson SC, Masopust D.
Nature. 2016 Apr 28;532(7600):512-6. doi: 10.1038/nature17655.
Published April 28, 2016
Dynamic T cell migration program provides resident memory within intestinal epithelium.
Masopust D, Choo D, Vezys V, Wherry EJ, Duraiswamy J, Akondy R, Wang J, Casey KA, Barber DL, Kawamura KS, Fraser KA, Webby RJ, Brinkmann V, Butcher EC, Newell KA, Ahmed R.
J Exp Med. 2010 Mar 15;207(3):553-64. doi: 10.1084/jem.20090858.
Published: March 15, 2010
Wall of Honor (200+ citations)
Standardized frozen preparation for transplantation of fecal microbiota for recurrent Clostridium difficile infection.
Hamilton MJ, Weingarden AR, Sadowsky MJ, Khoruts A.
Am J Gastroenterol. 2012 May;107(5):761-7. doi: 10.1038/ajg.2011.482. PMID: 22290405
Published: May 2012
Changes in the Composition of the Human Fecal Microbiome After Bacteriotherapy for Recurrent Clostridium difficile-associated Diarrhea
Khoruts, A; Dicksved J, Jansson JK, Sadowsky MJ.
JOURNAL OF CLINICAL GASTROENTEROLOGY Volume: 44 Issue: 5 Pages: 354-360
Published: May-June 2010
Transcriptional downregulation of S1pr1 is required for the establishment of resident memory CD8+ T cells.
Skon CN, Lee JY, Anderson KG, Masopust D, Hogquist KA, Jameson SC.
Nat Immunol. 2013 Dec;14(12):1285-93. doi: 10.1038/ni.2745. Epub 2013 Oct 27. PMID: 24162775
Published: December 2013
Cutting edge: Type IIFNs provide a third signal to CD8 T cells to stimulate clonal expansion and differentiation
Curtsinger, JM; Valenzuela JO, Agarwal P, Lins D, Mescher MF.
JOURNAL OF IMMUNOLOGY Volume: 174 Issue: 8 Pages: 4465-4469
Published: April 15, 2005
In vivo detection of dendritic cell antigen presentation to CD4(+) T cells
Ingulli E, Mondino A, Khoruts A, Jenkins MK.
JOURNAL OF EXPERIMENTAL MEDICINE Volume: 185 Issue: 12 Pages: 2133-2141
Published: June 16, 1997
Quantifying Memory CD8 T Cells Reveals Regionalization of Immunosurveillance.
Cell. 2015 May 7;161(4):737-49. doi: 10.1016/j.cell.2015.03.031. PMID: 25957682
Published: May 7, 2016
Inflammatory cytokines provide a third signal for activation of naive CD4(+) and CD8(+) T cells
Curtsinger, JM; Schmidt CS, Mondino A, Lins DC, Kedl RM, Jenkins MK, Mescher MF.
JOURNAL OF IMMUNOLOGY Volume: 162 Issue: 6 Pages: 3256-3262
Published: March 15, 1999
T cell memory. Resident memory CD8 T cells trigger protective innate and adaptive immune responses.
Science. 2014 Oct 3;346(6205):98-101. doi: 10.1126/science.1254536. Epub 2014 Aug 28. PMID: 25170049
Published: October 3, 2014
Antigen-independent differentiation and maintenance of effector-like resident memory T cells in tissues.
Casey KA, Fraser KA, Schenkel JM, Moran A, Abt MC, Beura LK, Lucas PJ, Artis D, Wherry EJ, Hogquist K, Vezys V, Masopust D.
J Immunol. 2012 May 15;188(10):4866-75. doi: 10.4049/jimmunol.1200402. Epub 2012 Apr 13. PMID: 22504644.
Published: May 15, 2012
Intravascular staining for discrimination of vascular and tissue leukocytes.
Nat Protoc. 2014 Jan;9(1):209-22. doi: 10.1038/nprot.2014.005. Epub 2014 Jan 2. PMID: 24385150
Published: January 2014
Carlson, C; Endrizzi BT, Wu J, Ding X, Weinreich MA, Walsh ER, Wani MA, Lingrel JB, Hogquist KA, Jameson SC.
NATURE Volume: 442 Issue: 7100 Pages: 299-302
Published: July 20, 2006
Sensing and alarm function of resident memory CD8⁺ T cells.
Schenkel JM, Fraser KA, Vezys V, Masopust D.
Nat Immunol. 2013 May;14(5):509-13. doi: 10.1038/ni.2568. Epub 2013 Mar 31. Erratum in: Nat Immunol. 2013 Aug;14(8):876. PMID: 23542740
Published: August 2013
A germinal center-independent pathway generates unswitched memory B cells early in the primary response.
J Exp Med. 2012 Mar 12;209(3):597-606. doi: 10.1084/jem.20111696. Epub 2012 Feb 27. PMID: 22370719
Published: March 12, 2012
Different routes of bacterial infection induce long-lived TH1 memory cells and short-lived TH17 cells.
Nat Immunol. 2010 Jan;11(1):83-9. doi: 10.1038/ni.1826. Epub 2009 Nov 22. PMID: 19935657
Published: January 2010
Critical role for CD8 in T cell receptor binding and activation by peptide/major histocompatibilitycomplex multimers.
Daniels MA, Jameson SC.
J Exp Med. 2000 Jan 17;191(2):335-46. PMID:10637277
Published: January 17, 2017
CD8 T cell clonal expansion and development of effector function require prolonged exposure to antigen, costimulation, and signal 3 cytokine.
J Immunol. 2003 Nov 15;171(10):5165-71. doi: 10.4049/jimmunol.171.10.5165.
Published: November 15, 2003
Cutting edge: intravascular staining redefines lung CD8 T cell responses.
J Immunol. 2012 Sep 15;189(6):2702-6. doi: 10.4049/jimmunol.1201682. Epub 2012 Aug 15. PMID: 22896631
Published: September 15, 2012
Tracking epitope-specific T cells.
Nat Protoc. 2009;4(4):565-81. doi: 10.1038/nprot.2009.9. PMID: 19373228
Published: December 9, 2012