2015 Publications

Plasmacytoid Dendritic Cells Require Direct Infection To Sustain the Pulmonary Influenza A Virus-Specific CD8 T Cell Response.
Hemann EA, Sjaastad LE, Langlois RA, Legge KL.
J Virol. 2015 Dec 30;90(6):2830-7. doi: 10.1128/JVI.02546-15.
PMID: 26719269

Bi-Allelic TCRα or β Recombination Enhances T Cell Development but Is Dispensable for Antigen Responses and Experimental Autoimmune Encephalomyelitis.
Schuldt NJ, Auger JL, Hogquist KA, Binstadt BA.
PLoS One. 2015 Dec 22;10(12):e0145762. doi: 10.1371/journal.pone.0145762. eCollection 2015.
PMID: 26693713

The Incubation Period of Primary Epstein-Barr Virus Infection: Viral Dynamics and Immunologic Events.
Dunmire SK, Grimm JM, Schmeling DO, Balfour HH Jr, Hogquist KA.
PLoS Pathog. 2015 Dec 1;11(12):e1005286. doi: 10.1371/journal.ppat.1005286. eCollection 2015 Dec.
PMID: 26624012

Progress in Adaptive Immunotherapy for Cancer in Companion Animals: Success on the Path to a Cure.
Anderson KL, Modiano JF.
Vet Sci. 2015 Dec;2(4):363-387. Epub 2015 Oct 19.
PMID: 27066495

Triptolide enhances the tumoricidal activity of TRAIL against renal cell carcinoma.
Brincks EL, Kucaba TA, James BR, Murphy KA, Schwertfeger KL, Sangwan V, Banerjee S, Saluja AK, Griffith TS.
FEBS J. 2015 Dec;282(24):4747-4765. doi: 10.1111/febs.13532. Epub 2015 Oct 18.
PMID: 26426449

Aberrant Retinoblastoma (RB)-E2F Transcriptional Regulation Defines Molecular Phenotypes of Osteosarcoma.
Scott MC, Sarver AL, Tomiyasu H, Cornax I, Van Etten J, Varshney J, O'Sullivan MG, Subramanian S, Modiano JF.
J Biol Chem. 2015 Nov 20;290(47):28070-83. doi: 10.1074/jbc.M115.679696. Epub 2015 Sep 16.
PMID: 26378234

Effective effector generation of CD8+ T cells and NK cells: A need for T-bet and ZEB-too.
Hamilton SE, Jameson SC.
J Exp Med. 2015 Nov 16;212(12):1990. doi: 10.1084/jem.21212insight3. No abstract available.

Therapeutic applications of TRAIL receptor agonists in cancer and beyond.
Amarante-Mendes GP, Griffith TS.
Pharmacol Ther. 2015 Nov;155:117-31. doi: 10.1016/j.pharmthera.2015.09.001. Epub 2015 Sep 5. Review.
PMID: 26343199

Pathobiology of Hemangiosarcoma in Dogs: Research Advances and Future Perspectives.
Kim JH, Graef AJ, Dickerson EB, Modiano JF.
Vet Sci. 2015 Nov 6;2(4):388-405. doi: 10.3390/vetsci2040388. Review.
PMID: 29061949

Mesenchymal stromal cells inhibit murine syngeneic anti-tumor immune responses by attenuating inflammation and reorganizing the tumor microenvironment.
Modiano JF, Lindborg BA, McElmurry RT, Lewellen M, Forster CL, Zamora EA, Schaack J, Bellgrau D, O'Brien TD, Tolar J.
Cancer Immunol Immunother. 2015 Nov;64(11):1449-60. doi: 10.1007/s00262-015-1749-6. Epub 2015 Aug 7.
PMID: 26250807

LynA regulates an inflammation-sensitive signaling checkpoint in macrophages.
Freedman TS, Tan YX, Skrzypczynska KM, Manz BN, Sjaastad FV, Goodridge HS, Lowell CA, Weiss A.
Elife. 2015 Oct 30;4. pii: e09183. doi: 10.7554/eLife.09183.

Sleeping Beauty transposon screen identifies signaling modules that cooperate with STAT5 activation to induce B-cell acute lymphoblastic leukemia.
Heltemes-Harris LM, Larson JD, Starr TK, Hubbard GK, Sarver AL, Largaespada DA, Farrar MA.
Oncogene. 2015 Oct 26. doi: 10.1038/onc.2015.405. [Epub ahead of print]

Ursodeoxycholic Acid Inhibits Clostridium difficile Spore Germination and Vegetative Growth, and Prevents the Recurrence of Ileal Pouchitis Associated With the Infection.
Weingarden AR, Chen C, Zhang N, Graiziger CT, Dosa PI, Steer CJ, Shaughnessy MK, Johnson JR, Sadowsky MJ, Khoruts A.
J Clin Gastroenterol. 2015 Oct 17. [Epub ahead of print]

Infectious Mononucleosis.
Dunmire SK, Hogquist KA, Balfour HH.
Curr Top Microbiol Immunol. 2015;390:211-40. doi: 10.1007/978-3-319-22822-8_9.

Generation of Th17 cells in response to intranasal infection requires TGF-β1 from dendritic cells and IL-6 from CD301b+ dendritic cells.
Linehan JL, Dileepan T, Kashem SW, Kaplan DH, Cleary P, Jenkins MK.
Proc Natl Acad Sci U S A. 2015 Oct 13;112(41):12782-7. doi: 10.1073/pnas.1513532112. Epub 2015 Sep 28.

Adaptive Immunity to Leukemia Is Inhibited by Cross-Reactive Induced Regulatory T Cells.
Manlove LS, Berquam-Vrieze KE, Pauken KE, Williams RT, Jenkins MK, Farrar MA.
J Immunol. 2015 Oct 15; 195(8):4028-37. doi: 10.4049/jimmunol.1501291. Epub 2015 Sep 16.

Negative Regulation of Memory Phenotype CD8 T Cell Conversion by Adhesion and Degranulation-Promoting Adapter Protein.
Fiege JK, Burbach BJ, Shimizu Y.
J Immunol. 2015 Oct 1; 195(7):3119-28. doi: 10.4049/jimmunol.1402670. Epub 2015 Aug 28

Tissue-Specific Distribution of iNKT Cells Impacts Their Cytokine Response.
Lee YJ, Wang H, Starrett GJ, Phuong V, Jameson SC, Hogquist KA.
Immunity. 2015 Sep 15;43(3):566-78. doi: 10.1016/j.immuni.2015.06.025. Epub 2015 Sep 8.

Nociceptive Sensory Fibers Drive Interleukin-23 Production from CD301b(+) Dermal Dendritic Cells and Drive Protective Cutaneous Immunity.
Kashem SW, Riedl MS, Yao C, Honda CN, Vulchanova L, Kaplan DH.
Immunity. 2015 Sep 15;43(3):515-26. doi: 10.1016/j.immuni.2015.08.016.  

The Neonatal CD4+ T Cell Response to a Single Epitope Varies in Genetically Identical Mice.
Nelson RW, Rajpal MN, Jenkins MK.
J Immunol. 2015 Sep 1;195(5):2115-21. doi: 10.4049/jimmunol.1500405. Epub 2015 Jul 15.

TCR affinity for thymoproteasome-dependent positively selecting peptides conditions antigen responsiveness in CD8(+) T cells.
Takada K, Van Laethem F, Xing Y, Akane K, Suzuki H, Murata S, Tanaka K, Jameson SC, Singer A, Takahama Y.
Nat Immunol. 2015 Oct;16(10):1069-76. doi: 10.1038/ni.3237. Epub 2015 Aug 24.
PMID: 26301566

T Cell Adolescence: Maturation Events Beyond Positive Selection.
Hogquist KA, Xing Y, Hsu FC, Shapiro VS.
J Immunol. 2015 Aug 15;195(4):1351-7. doi: 10.4049/jimmunol.1501050. Review.

The human T-cell repertoire grows up.  
Moon JJ, Jenkins MK. 
Immunol Cell Biol. 2015 Aug;93(7):601-2. doi: 10.1038/icb.2015.50. Epub 2015 May 5. No abstract available. 

Polymicrobial Sepsis Increases Susceptibility to Chronic Viral Infection and Exacerbates CD8+ T Cell Exhaustion.
Condotta SA, Khan SH, Rai D, Griffith TS, Badovinac VP.
J Immunol. 2015 Jul 1;195(1):116-25. doi: 10.4049/jimmunol.1402473. Epub 2015 May 15.
PMID: 25980007

Cutting edge: Bcl6-interacting corepressor contributes to germinal center T follicular helper cell formation and B cell helper function. 
Yang JA, Tubo NJ, Gearhart MD, Bardwell VJ, Jenkins MK. 
J Immunol. 2015 Jun 15;194(12):5604-8. doi: 10.4049/jimmunol.1500201. Epub 2015 May 11.

Investigating influenza A virus infection: tools to track infection and limit tropism.
Fiege JK, Langlois RA.
J Virol. 2015 Jun;89(12):6167-70. doi: 10.1128/JVI.00462-15. Epub 2015 Apr 8. Review.
PMID: 25855737

The frequency of naive and early-activated hapten-specific B cell subsets dictates the efficacy of a therapeutic vaccine against prescription opioid abuse.
Laudenbach M, Baruffaldi F, Vervacke JS, Distefano MD, Titcombe PJ, Mueller DL, Tubo NJ, Griffith TS, Pravetoni M.
J Immunol. 2015 Jun 15;194(12):5926-36. doi: 10.4049/jimmunol.1500385. Epub 2015 May 13.

Quantifying Memory CD8 T Cells Reveals Regionalization of Immunosurveillance.
Steinert EM, Schenkel JM, Fraser KA, Beura LK, Manlove LS, Igyártó BZ, Southern PJ, Masopust D.
Cell. 2015 May 7;161(4):737-49. doi: 10.1016/j.cell.2015.03.031.

Mast Cell Activation Disease and Microbiotic Interactions.
Afrin LB, Khoruts A.
Clin Ther. 2015 May 1;37(5):941-53. doi: 10.1016/j.clinthera.2015.02.008. Epub 2015 Mar 12. Review.

TCR ITAM multiplicity is required for the generation of follicular helper T-cells.
Hwang S, Palin AC, Li L, Song KD, Lee J, Herz J, Tubo N, Chu H, Pepper M, Lesourne R, Zvezdova E, Pinkhasov J, Jenkins MK, McGavern D, Love PE.
Nat Commun. 2015 May 11;6:6982. doi: 10.1038/ncomms7982.

Genome-wide association study identifies shared risk loci common to two malignancies in golden retrievers.
Tonomura N, Elvers I, Thomas R, Megquier K, Turner-Maier J, Howald C, Sarver AL, Swofford R, Frantz AM, Ito D, Mauceli E, Arendt M, Noh HJ, Koltookian M, Biagi T, Fryc S, Williams C, Avery AC, Kim JH, Barber L, Burgess K, Lander ES, Karlsson EK, Azuma C, Modiano JF, Breen M, Lindblad-Toh K.
PLoS Genet. 2015 Feb 2;11(2):e1004922. doi: 10.1371/journal.pgen.1004922. eCollection 2015 Feb. Erratum in: PLoS Genet. 2015 May;11(5):e1005339.
PMID: 25642983

Cutting edge: identification of autoreactive CD4+ and CD8+ T cell subsets resistant to PD-1 pathway blockade.
Pauken KE, Nelson CE, Martinov T, Spanier JA, Heffernan JR, Sahli NL, Quarnstrom CF, Osum KC, Schenkel JM, Jenkins MK, Blazar BR, Vezys V, Fife BT.
J Immunol. 2015 Apr 15;194(8):3551-5. doi: 10.4049/jimmunol.1402262. Epub 2015 Mar 13.

Stimulation with Concanavalin-A Induces IL-17 Production by Canine Peripheral T Cells.
Ritt MG, Lindborg BA, O'Brien TD, Bisignano J, Modiano JF.
Vet Sci. 2015 Apr 10;2(2):43-51. doi: 10.3390/vetsci2020043.
PMID: 29061930

Calnexin induces expansion of antigen-specific CD4(+) T cells that confer immunity to fungal ascomycetes via conserved epitopes.
Wüthrich M, Brandhorst TT, Sullivan TD, Filutowicz H, Sterkel A, Stewart D, Li M, Lerksuthirat T, LeBert V, Shen ZT, Ostroff G, Deepe GS Jr, Hung CY, Cole G, Walter JA, Jenkins MK, Klein B.
Cell Host Microbe. 2015 Apr 8;17(4):452-65. doi: 10.1016/j.chom.2015.02.009. Epub 2015 Mar 19.

Alterations in antigen-specific naive CD4 T cell precursors after sepsis impairs their responsiveness to pathogen challenge.
Cabrera-Perez J, Condotta SA, James BR, Kashem SW, Brincks EL, Rai D, Kucaba TA, Badovinac VP, Griffith TS.
J Immunol. 2015 Feb 15;194(4):1609-20. doi: 10.4049/jimmunol.1401711. Epub 2015 Jan 16.
PMID: 25595784                                                                                                                                                    

Humoral immunity. Apoptosis and antigen affinity limit effector cell differentiation of a single naïve B cell.
Taylor JJ, Pape KA, Steach HR, Jenkins MK.
Science. 2015 Feb 13;347(6223):784-7. doi: 10.1126/science.aaa1342. Epub 2015 Jan 29. 

Development of a novel anti-canine CD20 monoclonal antibody with diagnostic and therapeutic potential.
Ito D, Brewer S, Modiano JF, Beall MJ.
Leuk Lymphoma. 2015 Jan;56(1):219-25. doi: 10.3109/10428194.2014.914193. Epub 2014 Jun 16.
PMID: 24724777