Research Positions

Email: [email protected]

Program: Microbiology, Immunology, and Cancer Biology Graduate Student
Year Entered: 2019
Thesis Advisor: Ingunn Stromnes (lab website)

Research: Tumor cell loss of MHC class I remains is a critical barrier to successful immunotherapy. The goal of my research is to understand immune evasion of pancreatic ductal adenocarcinoma (PDA) and identify immune cell populations that either promote tumorigenesis or are critical for the anti-tumor immune response in MHC class I loss variants. Specifically, using an orthotopic model of PDA that expresses the click beetle neoantigen I will investigate how loss of MHC class I expression causes tumor escape and an unsuccessful immune response. Moreover, I hope to identify therapeutically targetable immune cells and pathways that can be leveraged to induce disease remission in MHC class I loss variants of PDA.

Degrees received: 
BA, Grinnell College, 2017

Zoe Schmiechen