Editorial: Immune mechanisms of inflammation in NASH.External link that opens in the same window
Hirsova P, Revelo XS.
Front Endocrinol (Lausanne). 2022 Sep 21;13:1039238. doi: 10.3389/fendo.2022.1039238. eCollection 2022.
PMID: 36213275

Effectiveness and Safety of Colonic and Capsule Fecal Microbiota Transplantation for Recurrent Clostridioides difficile Infection.External link that opens in the same window
Vaughn BP, Fischer M, Kelly CR, Allegretti JR, Graiziger C, Thomas J, McClure E, Kabage AJ, Khoruts A.
Clin Gastroenterol Hepatol. 2022 Sep 17:S1542-3565(22)00880-1. doi: 10.1016/j.cgh.2022.09.008. Online ahead of print.
PMID: 36126907

Non-criteria antiphospholipid antibodies and pediatric rheumatic disease: a case series.External link that opens in the same window
Mahmud SA, Bullock DR, Correll CK, Hobday PM, Riskalla MM, Vehe RK, Binstadt BA. 
Pediatr Rheumatol Online J. 2022 Aug 20;20(1):70. doi: 10.1186/s12969-022-00732-4.
PMID: 35987646

Functional virus-specific memory T cells survey glioblastoma. External link that opens in the same window
Ning J, Gavil NV, Wu S, Wijeyesinghe S, Weyu E, Ma J, Li M, Grigore FN, Dhawan S, Skorput AGJ, Musial SC, Chen CC, Masopust D, Rosato PC. 
Cancer Immunol Immunother. 2022 Aug;71(8):1863-1875. doi: 10.1007/s00262-021-03125-w. Epub 2022 Jan 10.
PMID: 35001153

Natural Killer Cell Antibody-Dependent Cellular Cytotoxicity (ADCC) Activity Against Plasmodium falciparum-Infected Red Blood Cells.External link that opens in the same window
Dick JK, Hart GT.
Methods Mol Biol. 2022;2470:641-657. doi: 10.1007/978-1-0716-2189-9_48.
PMID: 35881380

Type 2 cytokines in the thymus activate Sirpα+ dendritic cells to promote clonal deletion.External link that opens in the same window
Breed ER, Vobořil M, Ashby KM, Martinez RJ, Qian L, Wang H, Salgado OC, O'Connor CH, Hogquist KA.
Nat Immunol. 2022 Jul;23(7):1042-1051. doi: 10.1038/s41590-022-01218-x. Epub 2022 May 30.
PMID: 35637352

Targeted sequencing of candidate gene regions for myelofibrosis in dogs.External link that opens in the same window
Campbell AG, Seelig DM, Beckman JD, Minor KM, Heinrich DA, Friedenberg SG, Modiano JF, Furrow E.
J Vet Intern Med. 2022 Jul;36(4):1237-1247. doi: 10.1111/jvim.16476. Epub 2022 Jul 11.
PMID: 35815881

Immune tolerance of food is mediated by layers of CD4+ T cell dysfunction.External link that opens in the same window
Hong SW, Krueger PD, Osum KC, Dileepan T, Herman A, Mueller DL, Jenkins MK.
Nature. 2022 Jul;607(7920):762-768. doi: 10.1038/s41586-022-04916-6. Epub 2022 Jul 6.
PMID: 35794484

Retinoic acid signaling acts as a rheostat to balance Treg function.External link that opens in the same window
Thangavelu G, Andrejeva G, Bolivar-Wagers S, Jin S, Zaiken MC, Loschi M, Aguilar EG, Furlan SN, Brown CC, Lee YC, Hyman CM, Feser CJ, Panoskaltsis-Mortari A, Hippen KL, MacDonald KP, Murphy WJ, Maillard I, Hill GR, Munn DH, Zeiser R, Kean LS, Rathmell JC, Chi H, Noelle RJ, Blazar BR.
Cell Mol Immunol. 2022 Jul;19(7):820-833. doi: 10.1038/s41423-022-00869-y. Epub 2022 May 17.
PMID: 35581350

Combining nilotinib and PD-L1 blockade reverses CD4+ T-cell dysfunction and prevents relapse in acute B-cell leukemia.External link that opens in the same window
Tracy SI, Venkatesh H, Hekim C, Heltemes-Harris LM, Knutson TP, Bachanova V, Farrar MA.
Blood. 2022 Jul 28;140(4):335-348. doi: 10.1182/blood.2021015341.
PMID: 35275990

An OGT-STAT5 Axis in Regulatory T Cells Controls Energy and Iron Metabolism.External link that opens in the same window
Zhang Z, Salgado OC, Liu B, Moazzami Z, Hogquist KA, Farrar MA, Ruan HB.
Front Immunol. 2022 Jul 8;13:874863. doi: 10.3389/fimmu.2022.874863. eCollection 2022.
PMID: 35874700 

P2RX7 Enhances Tumor Control by CD8+ T Cells in Adoptive Cell Therapy.External link that opens in the same window
Wanhainen KM, Peng C, Zhou MH, Macedo BG, O'Flanagan S, Yang T, Kelekar A, Burbach BJ, Borges da Silva H, Jameson SC.
Cancer Immunol Res. 2022 Jul 1;10(7):871-884. doi: 10.1158/2326-6066.CIR-21-0691.
PMID: 35588154

Boosting corrects a memory B cell defect in SARS-CoV-2 mRNA-vaccinated patients with inflammatory bowel disease.External link that opens in the same window
Pape KA, Dileepan T, Matchett WE, Ellwood C, Stresemann S, Kabage AJ, Kozysa D, Evert C, Matson M, Lopez S, Krueger PD, Graiziger CT, Vaughn BP, Shmidt E, Rhein J, Schacker TW, Bold TD, Langlois RA, Khoruts A, Jenkins MK.
JCI Insight. 2022 Jun 22;7(12):e159618. doi: 10.1172/jci.insight.159618.
PMID: 35730567

Single-cell characterization of step-wise acquisition of carboplatin resistance in ovarian cancer.External link that opens in the same window
Wenzel AT, Champa D, Venkatesh H, Sun S, Tsai CY, Mesirov JP, Bui JD, Howell SB, Harismendy O.
NPJ Syst Biol Appl. 2022 Jun 17;8(1):20. doi: 10.1038/s41540-022-00230-z.
PMID: 35715421

CD47 Promotes Autoimmune Valvular Carditis by Impairing Macrophage Efferocytosis and Enhancing Cytokine Production.External link that opens in the same window
Meier LA, Faragher JL, Osinski V, Auger JL, Voeller R, Marath A, Binstadt BA.
J Immunol. 2022 Jun 15;208(12):2643-2651. doi: 10.4049/jimmunol.2100903. Epub 2022 Jun 3.
PMID: 35867674

Unravelling the sex-specific diversity and functions of adrenal gland macrophages.External link that opens in the same window
Dolfi B, Gallerand A, Firulyova MM, Xu Y, Merlin J, Dumont A, Castiglione A, Vaillant N, Quemener S, Gerke H, Stunault MI, Schrank PR, Kim SH, Zhu A, Ding J, Gilleron J, Magnone V, Barbry P, Dombrowicz D, Duranton C, Wakkach A, Blin-Wakkach C, Becher B, Pagnotta S, Argüello RJ, Rantakari P, Chakarov S, Ginhoux F, Zaitsev K, Kim KW, Yvan-Charvet L, Guinamard RR, Williams JW, Ivanov S.
Cell Rep. 2022 Jun 14;39(11):110949. doi: 10.1016/j.celrep.2022.110949.
PMID: 35705045

Macrophage Fate Mapping.External link that opens in the same window
Xu Y, Schrank PR, Williams JW.
Curr Protoc. 2022 Jun;2(6):e456. doi: 10.1002/cpz1.456.
PMID: 35687806

Differential hydrogen sulfide production by a human cohort in response to animal- and plant-based diet interventions.External link that opens in the same window
Teigen L, Mathai PP, Lopez S, Matson M, Elkin B, Kozysa D, Kabage AJ, Hamilton M, Vaughn BP, Sadowsky MJ, Khoruts A.
Clin Nutr. 2022 Jun;41(6):1153-1162. doi: 10.1016/j.clnu.2022.03.028. Epub 2022 Apr 5.
PMID: 35500315

Embracing the heterogeneity of natural viruses in mouse studies.External link that opens in the same window
Fiege JK, Langlois RA.
J Gen Virol. 2022 Jun;103(6). doi: 10.1099/jgv.0.001758.PMID: 35737518

Parabiosis in Mice to Study Tissue Residency of Immune Cells.External link that opens in the same window
Wang H, Gavil NV, Koewler N, Masopust D, Jameson SC.
Curr Protoc. 2022 May;2(5):e446. doi: 10.1002/cpz1.446.
PMID: 35612420

Respiratory Influenza Virus Infection Causes Dynamic Tuft Cell and Innate Lymphoid Cell Changes in the Small Intestine. External link that opens in the same window
Roach SN, Fiege JK, Shepherd FK, Wiggen TD, Hunter RC, Langlois RA.
J Virol. 2022 May 11;96(9):e0035222. doi: 10.1128/jvi.00352-22. Epub 2022 Apr 21
PMID: 35446142

Preclinical Efficacy and Selectivity of Vaccines Targeting Fentanyl, Alfentanil, Sufentanil, and Acetylfentanyl in Rats.External link that opens in the same window
Baehr C, Robinson C, Kassick A, Jahan R, Gradinati V, Averick SE, Runyon SP, Pravetoni M.
ACS Omega. 2022 May 4;7(19):16584-16592. doi: 10.1021/acsomega.2c00820. eCollection 2022 May 17.
PMID: 35601290

Comparative analysis of genome-wide DNA methylation identifies patterns that associate with conserved transcriptional programs in osteosarcoma.External link that opens in the same window
Mills LJ, Scott MC, Shah P, Cunanan AR, Deshpande A, Auch B, Curtin B, Beckman KB, Spector LG, Sarver AL, Subramanian S, Richmond TA, Modiano JF.
Bone. 2022 May;158:115716. doi: 10.1016/j.bone.2020.115716. Epub 2020 Oct 27.
PMID: 33127576

γδ Thymocyte Maturation and Emigration in Adult Mice. External link that opens in the same window
Joannou K, Golec DP, Wang H, Henao-Caviedes LM, May JF, Kelly RG, Chan R, Jameson SC, Baldwin TA.
J Immunol. 2022 May 1;208(9):2131-2140. doi: 10.4049/jimmunol.2100360. Epub 2022 Apr 8. 
PMID: 35396221

Gut microbial β-glucuronidases regulate host luminal proteases and are depleted in irritable bowel syndrome.External link that opens in the same window
Edwinson AL, Yang L, Peters S, Hanning N, Jeraldo P, Jagtap P, Simpson JB, Yang TY, Kumar P, Mehta S, Nair A, Breen-Lyles M, Chikkamenahalli L, Graham RP, De Winter B, Patel R, Dasari S, Kashyap P, Griffin T, Chen J, Farrugia G, Redinbo MR, Grover M.
Nat Microbiol. 2022 May;7(5):680-694. doi: 10.1038/s41564-022-01103-1. Epub 2022 Apr 28.
PMID: 35484230

Respiratory Influenza Virus Infection Causes Dynamic Tuft Cell and Innate Lymphoid Cell Changes in the Small Intestine.External link that opens in the same window
Roach SN, Fiege JK, Shepherd FK, Wiggen TD, Hunter RC, Langlois RA.
J Virol. 2022 May 11;96(9):e0035222. doi: 10.1128/jvi.00352-22. Epub 2022 Apr 21.
PMID: 35446142

Pharmacological Profiling of Antifentanyl Monoclonal Antibodies in Combination with Naloxone in Pre- and Postexposure Models of Fentanyl Toxicity.External link that opens in the same window
Baehr CA, Wu MM, Pandit SG, Arias-Umana J, AuCoin D, Pravetoni M.
J Pharmacol Exp Ther. 2022 May;381(2):129-136. doi: 10.1124/jpet.121.001048. Epub 2022 Feb 13.
PMID: 35153198

A dominant function of LynB kinase in preventing autoimmunity. External link that opens in the same window
Brian BF 4th, Sauer ML, Greene JT, Senevirathne SE, Lindstedt AJ, Funk OL, Ruis BL, Ramirez LA, Auger JL, Swanson WL, Nunez MG, Moriarity BS, Lowell CA, Binstadt BA, Freedman TS. 
Sci Adv. 2022 Apr 22;8(16):eabj5227. doi: 10.1126/sciadv.abj5227. Epub 2022 Apr 22. 
PMID: 35452291

Efficacy and Selectivity of Monovalent and Bivalent Vaccination Strategies to Protect against Exposure to Carfentanil, Fentanyl, and Their Mixtures in Rats.External link that opens in the same window
Crouse B, Wu MM, Gradinati V, Kassick AJ, Song D, Jahan R, Averick S, Runyon S, Comer SD, Pravetoni M.
ACS Pharmacol Transl Sci. 2022 Apr 20;5(5):331-343. doi: 10.1021/acsptsci.1c00260. eCollection 2022 May 13.
PMID: 35592436

Brown adipose tissue involution associated with progressive restriction in progenitor competence.External link that opens in the same window
Huang Z, Zhang Z, Moazzami Z, Heck R, Hu P, Nanda H, Ren K, Sun Z, Bartolomucci A, Gao Y, Chung D, Zhu W, Shen S, Ruan HB.
Cell Rep. 2022 Apr 12;39(2):110575. doi: 10.1016/j.celrep.2022.110575.
PMID: 35417710

The Conundrum of Lung Disease and Drug Hypersensitivity-like Reactions in Systemic Juvenile Idiopathic Arthritis.External link that opens in the same window
Binstadt BA, Nigrovic PA.
Arthritis Rheumatol. 2022 Apr 12. doi: 10.1002/art.42137. Online ahead of print.
PMID: 35413159

Epithelial STAT6 O-GlcNAcylation drives a concerted anti-helminth alarmin response dependent on tuft cell hyperplasia and Gasdermin C. External link that opens in the same window
Zhao M, Ren K, Xiong X, Xin Y, Zou Y, Maynard JC, Kim A, Battist AP, Koneripalli N, Wang Y, Chen Q, Xin R, Yang C, Huang R, Yu J, Huang Z, Zhang Z, Wang H, Wang D, Xiao Y, Salgado OC, Jarjour NN, Hogquist KA, Revelo XS, Burlingame AL, Gao X, von Moltke J, Lin Z, Ruan HB. 
Immunity. 2022 Apr 12;55(4):623-638.e5. doi: 10.1016/j.immuni.2022.03.009. Epub 2022 Apr 5.PMID: 35385697

Distinct myeloid antigen-presenting cells dictate differential fates of tumor-specific CD8+ T cells in pancreatic cancer.External link that opens in the same window
Burrack AL, Schmiechen ZC, Patterson MT, Miller EA, Spartz EJ, Rollins MR, Raynor JF, Mitchell JS, Kaisho T, Fife BT, Stromnes IM. 
JCI Insight. 2022 Apr 8;7(7):e151593. doi: 10.1172/jci.insight.151593. 
PMID: 35393950

SH3-domain mutations selectively disrupt Csk homodimerization or PTPN22 binding.External link that opens in the same window
Brian BF 4th, Sjaastad FV, Freedman TS.
Sci Rep. 2022 Apr 7;12(1):5875. doi: 10.1038/s41598-022-09589-9. 
PMID: 35393453

Differential hydrogen sulfide production by a human cohort in response to animal- and plant-based diet interventions.External link that opens in the same window
Teigen L, Mathai PP, Lopez S, Matson M, Elkin B, Kozysa D, Kabage AJ, Hamilton M, Vaughn BP, Sadowsky MJ, Khoruts A.
Clin Nutr. 2022 Apr 5;41(6):1153-1162. doi: 10.1016/j.clnu.2022.03.028. Online ahead of print.
PMID: 35500315

The Extracellular ATP Receptor P2RX7 Imprints a Promemory Transcriptional Signature in Effector CD8+ T Cells.External link that opens in the same window 
Vardam-Kaur T, van Dijk S, Peng C, Wanhainen KM, Jameson SC, Borges da Silva H.
J Immunol. 2022 Apr 1;208(7):1686-1699. doi: 10.4049/jimmunol.2100555. Epub 2022 Mar 9.
PMID: 35264459

Glucosamine facilitates cardiac ischemic recovery via recruiting Ly6Clow monocytes in a STAT1 and O-GlcNAcylation-dependent fashion.External link that opens in the same window
Zhou W, Jiang X, Tang Q, Ding L, Xiao W, Li J, Wu Y, Ruan HB, Shen Z, Chen W.
Clin Transl Med. 2022 Mar;12(3):e762. doi: 10.1002/ctm2.762. 
PMID: 35343077

Toll-like Receptor 7 and 8 Imidazoquinoline-Based Agonist/Antagonist Pairs. External link that opens in the same window
Yang M, Larson PG, Brown L, Schultz JR, Kucaba TA, Griffith TS, Ferguson DM. 
Bioorg Med Chem Lett. 2022 Mar 1;59:128548. doi: 10.1016/j.bmcl.2022.128548. Epub 2022 Jan 18.
PMID: 35051578

Examination of IgG Fc Receptor CD16A and CD64 Expression by Canine Leukocytes and Their ADCC Activity in Engineered NK Cells. External link that opens in the same window
Hullsiek R, Li Y, Snyder KM, Wang S, Di D, Borgatti A, Lee C, Moore PF, Zhu C, Fattori C, Modiano JF, Wu J, Walcheck B. 
Front Immunol. 2022 Feb 24;13:841859. doi: 10.3389/fimmu.2022.841859. eCollection 2022. 
PMID: 35281028

Redox regulation of age-associated defects in generation and maintenance of T cell self-tolerance and immunity to foreign antigens. External link that opens in the same window
Hester AK, Semwal MK, Cepeda S, Xiao Y, Rueda M, Wimberly K, Venables T, Dileepan T, Kraig E, Griffith AV. 
Cell Rep. 2022 Feb 15;38(7):110363. doi: 10.1016/j.celrep.2022.110363. 
PMID: 35172147

Insufficiency of compound immune checkpoint blockade to overcome engineered T cell exhaustion in pancreatic cancer.External link that opens in the same window
Stromnes IM, Hulbert A, Rollins MR, Basom RS, Delrow J, Bonson P, Burrack AL, Hingorani SR, Greenberg PD. 
J Immunother Cancer. 2022 Feb;10(2):e003525. doi: 10.1136/jitc-2021-003525.
PMID: 35210305

Characterization of influenza A virus induced transposons reveals a subgroup of transposons likely possessing the regulatory role as eRNAs. External link that opens in the same window
Shen SS, Nanda H, Aliferis C, Langlois RA. 
Sci Rep. 2022 Feb 9;12(1):2188. doi: 10.1038/s41598-022-06196-6. 
PMID: 35140280

Natural rodent model of viral transmission reveals biological features of virus population dynamics.External link that opens in the same window
Fay EJ, Balla KM, Roach SN, Shepherd FK, Putri DS, Wiggen TD, Goldstein SA, Pierson MJ, Ferris MT, Thefaine CE, Tucker A, Salnikov M, Cortez V, Compton SR, Kotenko SV, Hunter RC, Masopust D, Elde NC, Langlois RA.
J Exp Med. 2022 Feb 7;219(2):e20211220. doi: 10.1084/jem.20211220. Epub 2021 Dec 27. 
PMID: 34958350

Lung-resident memory B cells established after pulmonary influenza infection display distinct transcriptional and phenotypic profiles.External link that opens in the same window 
Tan HX, Juno JA, Esterbauer R, Kelly HG, Wragg KM, Konstandopoulos P, Alcantara S, Alvarado C, Jones R, Starkey G, Wang BZ, Yoshino O, Tiang T, Grayson ML, Opdam H, D'Costa R, Vago A; Austin Liver Transplant Perfusionist Group, Mackay LK, Gordon CL, Masopust D, Groom JR, Kent SJ, Wheatley AK. 
Sci Immunol. 2022 Jan 28;7(67):eabf5314. doi: 10.1126/sciimmunol.abf5314. Epub 2022 Jan 28.
PMID: 35089815

Engagement of the costimulatory molecule ICOS in tissues promotes establishment of CD8+ tissue-resident memory T cells.External link that opens in the same window 
Peng C, Huggins MA, Wanhainen KM, Knutson TP, Lu H, Georgiev H, Mittelsteadt KL, Jarjour NN, Wang H, Hogquist KA, Campbell DJ, Borges da Silva H, Jameson SC.
Immunity. 2022 Jan 11;55(1):98-114.e5. doi: 10.1016/j.immuni.2021.11.017. Epub 2021 Dec 20.
PMID: 34932944

Sphingosine 1-phosphate receptor 5 (S1PR5) regulates the peripheral retention of tissue-resident lymphocytes.External link that opens in the same window
Evrard M, Wynne-Jones E, Peng C, Kato Y, Christo SN, Fonseca R, Park SL, Burn TN, Osman M, Devi S, Chun J, Mueller SN, Kannourakis G, Berzins SP, Pellicci DG, Heath WR, Jameson SC, Mackay LK.
J Exp Med. 2022 Jan 3;219(1):e20210116. doi: 10.1084/jem.20210116. Epub 2021 Oct 22.
PMID: 34677611